Journal Reviews

Malignant transformation of leukoplakia in previous cancer patients

10 March 2023 | | Head and Neck | carbon dioxide laser, history, neoplastic cell transformation, oral leukoplakia, oral squamous cell carcinoma

This is a retrospective study from Taiwan assessing risk factors in developing oral squamous cell carcinoma from surgically excised oral leukoplakia in patients with a previous oral cancer, the underlying thought being that patients with an oral carcinoma have a...

Dysphagia journal cover image.

Dysphagia in people with HPV-related oropharyngeal cancer

3 May 2022 | | Laryngology / Swallowing / Voice | Dysphagia, EAT-10, Human papillomavirus, Oropharyngeal squamous cell carcinoma

Human papilloma virus (HPV) associated oropharyngeal cancers are becoming much more prevalent and, in some geographic areas, have overtaken tobacco as the leading cause of oropharyngeal cancer. HPV-associated cancers are also reported to have better prognosis in general, and research...

Clinical pathological features associated with malignant change in oral leukoplakias

2 March 2022 | | Head and Neck | carcinoma, leukoplakia, mouth neoplasms, oral, Oral squamous cell carcinoma

This is a retrospective study from Sweden where 234 patients, diagnosed between 2003 and 2013 with a median nine-year follow-up, were reviewed. Of these 234 patients, 11.5% developed oral squamous cell carcinoma. Non-homogenous leukoplakia showed a 15-times higher transformation rate...

Narrow band imaging in the management of carcinoma of unknown primary

4 May 2021 | | Head and Neck, Rhinology / Sinus | carcinoma of unknown primary, head and neck squamous cell carcinoma, narrowband imagin, transoral robotic surgery

This was a retrospective study to assess the utility of narrow band imaging (NBI) in the detection of a primary site in carcinoma of unknown primary (CUP). Patients with CUP who underwent transoral robotic surgery (TORS) and preoperative imaging with...

B-Ent journal cover image.

PET-CT for malignant nasopharyngeal lesions

7 January 2021 | | Head and Neck, Rhinology / Sinus, Skull Base Surgery | Biopsy, nasopharyngeal carcinoma, PET/CT

This retrospective Turkish review of 92 patients aimed to determine the ability of fluorine 18-fluorodeoxyglucose (FDG) maximum standardised uptake value (SUVmax) on positron emission tomography/computerised tomography (PET/CT) to differentiate benign processes and malignant nasopharyngeal lesions. The authors retrospectively reviewed the...

Intraoperative identification of primary tumours in unknown primary head and neck cancer using transoral laser microsurgery with frozen sections

30 April 2020 | | Head and Neck | head and neck cancer, intraoperative margin assessment, squamous cell carcinoma, transoral laser microsurgery, unknown primary tumor

The aim of the study was to compare the sensitivity and specificity of intraoperative identification of primary tumours in patients with unknown primary head and neck squamous cell carcinoma (UP HNSCC) using transoral laser microsurgery (TLM) with frozen sections, with...

OTOLARYNGOLOGY- HEAD AND NECK SURGERY cover image

Elevated prevalence of late-onset dysphagia among head and neck cancer survivors and identifying risk factors

7 January 2020 | | Head and Neck | dysphagia, head and neck cancer, late effects, squamous cell carcinoma, survivorship

Dysphagia is one of the most common problems affecting head and neck cancer (HNC) survivors. There are few studies investigating late-onset dysphagia post-treatment. The authors set out to investigate the prevalence of dysphagia-related diagnoses and procedures five years’ post-treatment, changes...

Delays in oral cancer

1 November 2019 | | Head and Neck | Oral cancer, patient delay, professional delay, squamous cell carcinoma, treatment delay

This is a review from Canada where they attempt to relate delays in oral cancer presentation to treatment and the impact on stage, diagnosis and survival. They recognise that potentially the most significant delay is between the patient first noticing...

British Journal of Oral and Maxillofacial Surgery cover

Significance of abnormal retropharyngeal nodes in head and neck cancer

1 November 2019 | | Rhinology / Sinus | nasopharyngeal cancer, oral, oropharyngeal, retropharyngeal nodes, squamous cell carcinoma

Abnormal retropharyngeal lymph nodes (RLN) have prognostic relevance for patients with oral, oropharyngeal or nasopharyngeal squamous cell carcinoma (SCC). However, consensus on the evaluation and management of abnormal RLN in these patients is lacking. The authors of this paper provided...

Is bone scanning still of value?

1 September 2019 | | Head and Neck | bone invasion, computed tomography, magnetic resonance imaging, oral, squamous cell carcinoma

This is an article from Australia of 109 patients, 83 of which had CT, 72 MRI and the presence of bone invasion on imaging was compared with the histopathology. Bone invasion was present in 44 of 109 resection specimens. Bone...

Sinonasal undifferentiated carcinoma – slowly getting there

1 January 2019 | | induction chemotherapy, multicenter study, multimodal approach, sinonasal undifferentiated carcinoma, sinus cancer

The rarest of the rare, sinonasal tumours form only a small part of the total number of head and neck tumours and undifferentiated carcinoma (SNUC) is one of the rarest of this group. There is some data (and some expert...

Investigation of the role of KPNA2 biomarker in oral SCC invasiveness

1 October 2018 | | Head and Neck | interleukin-1β (IL-1β), invasiveness, karyopherin alpha 2 (KPNA2), matrix metalloproteinase (MMP), oral cavity squamous cell carcinoma (SCC), survival

This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...

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