Hassan Mohammed

ENT SpR

North East Deanery, Newcastle, UK.

Latest Contribution

Allergy journal cover image

Allergic rhinitis, the usual suspects

27 February 2020 | | Rhinology / Sinus | allergic rhinitis, cysteinyl leukotriene, eosinophil, group 2 innate lymphoid cells, prostaglandin D2

Allergic rhinitis (AR) is characterised by allergen binding to IgE on mast cells and basophils and subsequent histamine, prostaglandine D2 (PGD2) and cysteinyl leukotrienes (cysLTs) release causing early-phase response. This is followed by late-phase response mediated by eosinophils. Other cells,...

ALLERGY cover

The hippo and the nose

1 November 2019 | | Speech and Language Therapy | Hippo-YAP pathway, cell proliferation, epithelial cells, epithelium remodeling, nasal polyps

Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...

ALLERGY cover

Chronic rhinitis endotypes

1 November 2019 | | Auditory Implants | chronic rhinitis, cluster analysis, endotype, local IgE, serum IgE

Chronic rhinitis (CR) is common with up to 30% of the population affected, with a significant impact on quality of life. CR includes several phenotypes with different pathogenesis including allergy, autoimmune, age, occupation, pregnancy, neurogenic and drugs. Such variation means...