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Eosinophilic complications during dupilumab therapy
Dupilumab is a humanised monoclonal antibody that targets type 2 inflammation by blocking IL-4 and IL-13 signalling. Reported adverse events from its use include injection site erythema, conjunctivitis, arthralgia and hypereosinophilia. The potential for more severe eosinophilic-related complications such as...Biologic therapies for chronic rhinosinusitis with nasal polyps: a new paradigm
Surgery for nasal polyposis has evolved significantly in the last 30 years, and now the medical management may be on the cusp of a revolution. Biologics using monoclonal antibodies to target specific immune pathways have introduced a paradigm shift in...
App-solute relief: tackling tinnitus with your smartphone
The sound experienced by individuals with tinnitus can vary to a huge extent. It can range from a mild occasional ringing to a constant, loud noise causing disruption to daily life and sleep. Reassuringly, tinnitus is rarely a sign of...
The stubborn polyp cases are ‘different’
The widely different behaviour of nasal polyp disease between patients is a major feature of rhinology practice and makes counselling of patients difficult when approaching their first operative intervention. Setting aside aspirin sensitivity (Samter’s triad), which is known to be...
Patient factors associated with spontaneous CSF leak
This article highlights the role of obesity, sleep apnoea and raised intracranial pressure as linked pathologies in the aetiology of the spontaneous cerebrospinal fluid (sCSF) leak. The authors link sCSF leak with obesity and comment on sCSF leak incidence increasing...Neuromod advances multiple regulatory approvals to expedite Lenire’s global availability
Neuromod, the medical technology company that created the Lenire® tinnitus treatment device, has announced approval to the Medical Device Single Audit Program (MDSAP) and EU Medical Device Regulation (MDR) certification. Neuromod’s MDSAP certification follows a comprehensive audit verifying compliance with...
Review: Cochlear Implantation in SSD?
Contra lateral routing of signals (CROS) using hearing aids and bone conduction devices has been the conventionally accepted modality for the treatment of single sided hearing impairment. The CROS hearing aid has been found to improve speech understanding in noise,...
How can we improve outcomes for patients with acute vestibular neuritis?
Vestibular neuritis is a common disorder that can leave up to 50% of patients with persistent vertigo symptoms for months to years following the acute insult. Often their first contact with ENT or balance specialists is many months after the...
Saline irrigation in CRSwNP after surgery
This article, largely from Germany, aims to prove the effectiveness of nasal saline irrigation in postoperative patients with CRS with nasal polyps. A prospective, single blinded randomised trial was designed with an irrigation and non-irrigation arm. Patients who underwent sinonasal...
Day care stapes surgery
This paper reports on a proposed unblinded, randomised controlled trial in which the hearing outcomes after inpatient stapes surgery will be compared with those after day case stapes surgery. The study is currently in the recruitment stage and plans to...
