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Changing perceptions in head and neck cancer management caused by quality of life issues
Sir Felix Semon was an outstanding clinician and exceptional laryngologist. The money raised by donations from his colleagues on his retirement in 1909 was used to establish the London University’s Semon Lecture. Semon’s Obituary in the BMJ, reads: “In Semon's...
Association between depression and survival in patients with head and neck cancer
Approximately 40% of patients develop major depressive disorder (MDD) during diagnosis and treatment for head and neck cancer (HNC). Depressive symptoms in these patients have a significant effect on their rehabilitation and survival. Given the small number of studies in...
Impact of the updated cancer staging system on HPV-positive disease
The AJCC cancer staging manual was updated in 2017 (8th edition). It is used in the MDT setting for planning treatment and assessing prognosis for individual patients, and is also widely used internationally in clinical trials. Unlike previous iterations of...
Association of quality of life with type of surgical treatment in patients with differentiated thyroid cancer
Standard treatment for differentiated thyroid cancer (DTC) is surgery, which includes either a total thyroidectomy or hemithyroidectomy. Surgery may then be followed by radioactive iodine treatment and, for some, treatment with thyroid hormone to suppress thyrotropin levels. All patients undergoing...
Should we reconsider induction chemotherapy in advanced stage laryngeal cancer?
Use of chemo-radiotherapy for advanced laryngeal cancer led to a major shift in treatment as an alternative to total laryngectomy. Despite widespread adoption of chemoradiotherapy, survival rates have not improved and the original premise of matching neoadjuvant chemotherapy tumour response...
Are there benefits of prophylactic swallowing exercises for patients with head and neck cancer?
This randomised controlled trial aimed to establish the impact of prophylactic swallowing exercises in patients undergoing chemoradiation therapy for head and neck cancer. The primary outcome was the functional oral intake scale (FOIS), although secondary measures for feeding tube use,...
Prognostic value of neutrophil-to-lymphocyte ratio in HPV-positive oropharyngeal cancer
The authors propose that high neutrophil-to-lymphocyte ratio (NLR) is associated with poor disease-free survival (DFS) in patients with human papillomavirus positive (HPV+) oropharyngeal cancer (OPC). This is a retrospective study that compared the outcomes of 43 patients treated for HPV+...
Preoperative imaging for thyroid cancer according to 2015 ATA guidelines
The 2015 American Thyroid Association (ATA) management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer suggest that thyroid sonography with survey of the cervical lymph nodes should be performed in all patients with known or suspected thyroid...
Best timing for post-treatment PET-CT scans in head and neck cancer
Unfortunately we know that the recurrence rate for head and neck cancer can be high, up to 30-50% in some series. These recurrences tend to occur within the first two years following treatment. Optimal surveillance strategies to detect recurrences early...
What is the right balance to strike in the management of anaplastic thyroid cancer?
This is a pragmatic article on a difficult and much debated subject. Management of anaplastic thyroid cancer (ATC) can feel like making decisions between a rock and a hard place, and this article suggests one path to help navigate some...
