Investigation of the role of KPNA2 biomarker in oral SCC invasiveness

This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...

Using evidence and international consensus to guide treatment of thyroid nodules

The authors of this practical review paper highlight a growing issue within thyroid surgery, where high-quality ultrasound has increased the detection of subclinical nodules: what do we do with the patient presenting with an ‘incidental’ thyroid nodule? This has both...

Risk of second primary cancer among patients with head and neck cancers

Patients with head and neck squamous cell carcinoma (HNSCC) have an elevated risk of developing a second primary malignant neoplasm (SPMN). These are of increasing concern because the number of survivors of HNSCC has been growing owing to early detection...

When to treat a fractured mandible?

This is a prospective study from Brisbane of 215 patients with a total of 359 fractures of the mandible. Nine outcome variables were analysed with a further 19 included to adjust for potential confounding. Treatment delay was found not to...

Delirium post-op

This is a retrospective study from Japan analysing 102 patients who underwent oral cancer resection and free flap reconstruction. Postoperative delirium occurred in a third of these patients. An increased risk was identified in those with high preoperative albumin, postoperative...

Modified subciliary approach to the orbital floor

Fractures involving the lateral midface and orbital floor are routinely treated by maxillofacial surgeons. The surgical management requires access to the facial skeleton to reposition and free the soft tissues. There are three main approaches to the orbital floor: infraorbital;...

Is a chest x-ray necessary in making urgent referrals for suspected head and neck cancer?

The article presents an audit on urgent referrals for suspected head and neck cancer in 2144 patients. Only 8.6% of cases proved positive for head and neck cancer. The Scottish Referral Guidelines were adhered only in 55.1% of cases. Interestingly,...

Current management of facial fractures in the preadolescent

This article reviews the trends in management of preadolescent facial fractures – a challenging population due to the need to consider growth, dynamic changes in dentition, and evolving fracture patterns. In summary, conservative management is preferred in all fractures in...

Facial Landmark localisation by curvature maps and profile analysis

The detection of three dimensional (3D) landmarks by scanning surfaces is a well established method in medical science. Anatomical landmarks are visually or palpably detectable and act as reference points for clinical measurements. When measuring these landmarks with a sliding...

The stigma of HPV in oral cancer

The increase of oropharyngeal carcinoma (OPC) in the developed world seems to be largely caused by infection with the human papillomavirus (HPV). HPV is a group of 150 DNA viruses that are common and most people will be infected at...

Proliferative Verrucous Leukoplakia; which one is this one?

Oral leukoplakia has the potential for malignant change and it may frequently require histological analysis and a period of regular clinical observation. The majority of oral leukoplakia remains constant but there is a subset that progress to carcinoma. The authors...

Use of angular vessels in head and neck free-tissue transfer – a comprehensive preclinical evaluation

Free tissue transfer (FTT) has transformed the capabilities in head and neck reconstruction. Rotational and pedicled flaps are limited by the pedicle length, the type of tissue required and the size of the defect. FTT helps lessen the impact of...

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