Hassan Mohammed

ENT SpR

North East Deanery, Newcastle, UK.

Latest Contribution

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Chronic rhinitis endotypes

1 November 2019 | | Auditory Implants | chronic rhinitis, cluster analysis, endotype, local IgE, serum IgE

Chronic rhinitis (CR) is common with up to 30% of the population affected, with a significant impact on quality of life. CR includes several phenotypes with different pathogenesis including allergy, autoimmune, age, occupation, pregnancy, neurogenic and drugs. Such variation means...

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CRSwNP, another monoclonal antibody

1 July 2019 | | Rhinology / Sinus | biomarkers, dupilumab, nasal polyposis, nasal secretions, type 2 inflammation

Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...

CRSwNP and smell – is it just the obstruction?

1 May 2019 | | Neurotology, Otology, ENT, Skull Base Surgery | Type 2/Th2 inflammation, chronic rhinosinusitis, olfaction, olfactory epithelium, sensory neurogenesis

Anosmia and hyposmia are symptoms of CRS both with and without nasal polyps and can significantly affect quality of life. The nature of anosmia/hyposmia is thought to be both sensory-neural and conductive. These authors studied a mouse model in which...