Hassan Mohammed

ENT SpR

North East Deanery, Newcastle, UK.

Latest Contribution

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The hippo and the nose

1 November 2019 | | Speech and Language Therapy | Hippo-YAP pathway, cell proliferation, epithelial cells, epithelium remodeling, nasal polyps

Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...

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Chronic rhinitis endotypes

1 November 2019 | | Auditory Implants | chronic rhinitis, cluster analysis, endotype, local IgE, serum IgE

Chronic rhinitis (CR) is common with up to 30% of the population affected, with a significant impact on quality of life. CR includes several phenotypes with different pathogenesis including allergy, autoimmune, age, occupation, pregnancy, neurogenic and drugs. Such variation means...

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CRSwNP, another monoclonal antibody

1 July 2019 | | Rhinology / Sinus | biomarkers, dupilumab, nasal polyposis, nasal secretions, type 2 inflammation

Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...