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Investigation of the role of KPNA2 biomarker in oral SCC invasiveness
This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...
Predicting the need for salvage laryngectomy
The treatment of laryngeal cancer has seen a shift towards organ preservation strategies with non-surgical treatment offering equivalent survival outcomes. Nonetheless, salvage total laryngectomy (SLT) remains an important curative management option in cases of treatment failure or recurrence. The authors...
Does transoral robotic surgery improve outcomes among patients with head and neck cancer of unknown primary?
A tonsillectomy and tongue base mucosectomy is becoming increasingly accepted as the optimal surgical intervention to aid in identifying the primary source of a p16+ / HPV-related squamous cell carcinoma (SCC) of unknown origin, given that this disease almost exclusively...
Adjuvant radiotherapy for T4N0 laryngeal cancers treated with laryngectomy
A total laryngectomy remains the gold standard for the initial treatment of advanced (T4) squamous cell carcinomas of the larynx without evidence of distant disease. Adjuvant radiotherapy (RT) is also recommended for such cancers. In the absence of other adverse...
Dysplasia at the margins of laryngeal cancer specimens following laser resection – is conservative management appropriate?
Transoral laser microsurgery (TOLM) remains the cornerstone of treatment for early laryngeal squamous cell carcinomas. Whilst the hope is always to achieve a complete surgical excision with clear margins, it is sometimes the case that on histological analysis, disease is...
On-call ENT apps
ENT apps for trainees are few and far between. Here are a couple of them which could be useful for the on-call. ENTSHO.com Born out of the website with the same name, this app is a must-have if you work...Current considerations on neural development and hearing loss in young children
The young child’s brain has the ability to change in response to new stimuli, resulting in learning, the foundation of adaptive and intelligent behaviour. For children with hearing loss, a reduction or lack of auditory stimuli can have a ‘lifelong...
