You searched for "Cell"

2310 results found

A funny thing happened on the way to a conference – and other stories

This series of stories is dedicated to those of you with whom some of these moments were shared (or endured) and, above all, to my amazing and long-suffering husband, David Howard. Most of you know him as an exceptional head...

Total Otolaryngology - Head and Neck Surgery

This single volume, 1098 page book with 667 illustrations, covers all aspects of otolaryngology in both theory and practice. Compiled together by a team of world renowned co-editors from North America, as well as authors from differing specialities, this book...

An idiot’s guide to the Ministry of Health

Neville Chamberlain on an ill-judged charm offensive. Now I like to consider myself a well brought up sort of chap, and was always taught never to bring up religion, politics or (heaven forfend!) a lady’s name at the dinner table....

The initial electroneuronography result after temporal bone trauma related facial palsy may be misleading

It is taught that a complete facial nerve (FN) palsy after temporal bone (TB) trauma should be conservatively managed if electroneuronography (ENoG) shows a less than 90% degeneration of response compared to the contralateral side. This small study from the...

Advances in surgical innovation for head and neck cancer

This article reviews current advances in surgical treatment of head and neck cancers such as sentinel node biopsy, stereolithic modelling, transoral robotic surgery and intra-operative imaging of tumour margins. Sentinel node biopsy has been found to be especially useful for...

A mouth-rinse test that can screen for oral cancer?

This paper presents a promising screening tool for oral cancer – using a simple chlorhexidine mouth-rinse. The hypermethylated ZNF582 and PAX1 markers were chosen based on previous studies using oral scraping methods of collection and have been shown to be...

Management of the neck in maxillary sinus carcinomas

Primary malignant tumours of the sinonasal tract account for less than 10% of head and neck cancers, of which the maxilla is the second most common subsite and squamous cell carcinoma (SCC) is the most prevalent histological type. Maxillary SCCs...

Depth of invasion of oral cancer should be incorporated in new AJCC staging system

Since 1977, when the first edition of the Manual for Staging of Cancer was published by the American Joint Committee on Cancer (AJCC), the primary tumour staging for oral squamous cell carcinoma (SCC) has remained unchanged. In the last four...

External auditory canal carcinoma

Although uncommon, primary malignant tumours of the external auditory canal (EAC) are associated with a poor prognosis as they often present late. In this study the authors evaluate the clinical and pathological factors associated with treatment and outcome of EAC...

Investigation of the role of KPNA2 biomarker in oral SCC invasiveness

This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...

Predicting the need for salvage laryngectomy

The treatment of laryngeal cancer has seen a shift towards organ preservation strategies with non-surgical treatment offering equivalent survival outcomes. Nonetheless, salvage total laryngectomy (SLT) remains an important curative management option in cases of treatment failure or recurrence. The authors...

Does transoral robotic surgery improve outcomes among patients with head and neck cancer of unknown primary?

A tonsillectomy and tongue base mucosectomy is becoming increasingly accepted as the optimal surgical intervention to aid in identifying the primary source of a p16+ / HPV-related squamous cell carcinoma (SCC) of unknown origin, given that this disease almost exclusively...