Journal Reviews

American Journal of Otolaryngology cover image.

A new era in the treatment of recalcitrant nasal polyps?

8 November 2021 | | Laryngology / Swallowing / Voice, Rhinology / Sinus | IgE, SNOT-22, aspirin-exacerbated respiratory disease, chronic rhinosinusitis with nasal polyps, mild asthma, nasal polyps, omalizumab, quality of life, tissue eosinophilia, total nasal endoscopic polyp score

Chronic rhinosinusitis with nasal polyps (CRSwNP) can be difficult to treat effectively in patients with aggressive or recalcitrant disease. Omalizumab (Xolair) is a monoclonal anti-IgE antibody with proven benefits for patients with moderate/severe asthma and CRSwNP, but this study looks...

Allergy journal cover image.

Biologicals for severe chronic rhinosinusitis with nasal polyps. Any use?

5 November 2021 | | Rhinology / Sinus | chronic rhinosinusitis, dupilumab, mepolizumab, omalizumab, reslizumab

Recent advances and knowledge of inflammatory endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) led to introduction of biological agents such as monoclonal antibodies targeting IgE (omalizumab) and Interleukins (ILs) such as IL4R alpha (dupilumab) and IL5. The European Academy...