You searched for "Cell"
A drug to prevent hearing loss caused by ototoxic therapeutics
This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...
IL-25 and nasal polyps, another target
Immune response in chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly via type 2 T-helper (Th2) cells while Th1 cells characterise chronic rhinosinusitis without nasal polyps (CRSsNP) immune response. CRSwNP is heterogeneous on a cytological level causing a varied response...
What can the anterior cranial fossa fracture pattern tell us?
This assessment involves 81 patients treated between two regional major trauma centres in the UK. Fifty sustained a predominantly anterior directed force and 31 a lateral impact. They found that anterior impacts reduce the incidence of fracture propagated beyond the...
Adenotonsillectomy can improve ADHD and nocturnal enuresis
The link between chronic adenotonsillar hypertrophy (CAH) and behavioural disturbance is well recognised. Several studies have found that CAH has been associated with attention deficit hyperactivity disorder (ADHD) and treatment of CAH may diminish symptoms of ADHD in a subset...
Diagnostic performance of non-echo-planar diffusion weighted MRI in detection of suspected cholesteatoma
Even though a ‘second look’ remains a gold standard for detection of residual cholesteatoma after intact canal wall techniques, non-echo-planar diffusion weighted MRI is considered a reasonable alternative to avoid further surgery. However, to establish or exclude a cholesteatoma de...
Corticosteroid prescribing in ENT - are we at risk of being sued?
Of medications leading to malpractice claims, corticosteroids comprise the third most common. They are used widely and have a significant side-effect profile: hypertension, lipodystrophy, diabetes, avascular necrosis of the femoral head, peptic ulceration and psychiatric reactions to name but a...
Anatomy and Physiology of Speech and Hearing
This American book is written for students “in the field of communication sciences and disorders”, however, this is a very useful text for anyone wanting to understand the underpinning science behind speech, swallowing and hearing and balance. The book is...
Sentinel nodes and UADT tumours
This is the review of a multicentre study to set practical guidelines for sentinel node techniques (SLN) in upper aerodigestive tract (UADT) squamous cell carcinomas including classical and extended indications. SLN biopsies are strictly indicated in patients with clinically and...
5-cm incision for neck dissection and free flap reconstruction
Patients with oral cavity squamous cell carcinoma (SCC) will commonly require neck dissection as it is associated with a higher rate of overall and disease free survival. Free flap reconstruction of the defect following surgical resection is considered the gold...
The role of imaging in differentiating rare temporal bone neoplasms
This paper provides a useful tool to assist in determining the diagnosis of benign neoplasms of the temporal bone using readily available imaging modalities. Specifically, this group have looked at chondrosarcoma, an expansile hypermetabolic mass lesion usually found in the...
Radiation-induced dysphagia in head and neck cancer
This is a helpful reference paper that provides an overview of the biomolecular effects of radiation on the tissues of the upper aero-digestive tract. The authors explain that radiation injuries occur in a repetitive and accruing manner over the duration...
