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Omalizumab for CRSwNP: a monoclonal antibody

A prospective study from London, evaluating the response of chronic rhinosinusitis patients with nasal polyposis who were being treated with monoclonal antibody against IgE for severe allergic asthma. Thirteen patients were treated with Omalizumab, according to UK guidelines for their...

Facial pain and headaches

This paper reviews the present knowledge and the recent publications on the cause, characteristics, course and treatment of chronic and recurring facial pain and headaches. Facial pain should be defined in terms of frequency, duration and severity, and also in...

The hippo and the nose

Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...

Allergic rhinitis, the usual suspects

Allergic rhinitis (AR) is characterised by allergen binding to IgE on mast cells and basophils and subsequent histamine, prostaglandine D2 (PGD2) and cysteinyl leukotrienes (cysLTs) release causing early-phase response. This is followed by late-phase response mediated by eosinophils. Other cells,...

Loss of smell in the age of COVID-19

Loss of smell (LOS) is a debilitating symptom with increasing interest for the medical community due to its high prevalence in COVID-19. In the present paper, a team of 15 experts provide recommendations for the investigation and management of patients...

Is wine blocking your nose?

Salicylates are commonly found in a wide variety of foods, such as unripe fruit, vegetables, nuts, seeds and spices. They play a role in growth and development of plants, photosynthesis, transpiration, ion uptake and transport. Non-steroidal exacerbated respiratory disease (N-ERD)...

Endoscopic ‘syringe and cutdown’ technique for nasolacrimal duct obstruction in children

This article presents a novel yet simple technique to help in the management of congenital NLDO. The authors propose it as a valuable addition to existing standard procedures. Congenital nasolacrimal duct obstruction (NLDO) is a condition encountered within the first...

Office treatment for persistent rhinorrhoea

Vasomotor rhinitis (VR) is a common condition across the world. Patients suffering from VR commonly have symptoms of persistent bilateral rhinorrhoea, that can have a significant negative impact on their quality of life. Vasomotor rhinitis can be treated medically with...

Merocel vs Cutanplast Anal packing

This study compared two different nasal dressings after septoplasty. Seventy-six patients acted as their own controls by having one nostril packed with Merocel and one nostril somewhat improbably with Cutanplast Anal (gelatin sponge). It seems that the gelatin sponge was...

Identification of congenital hearing loss in Saudi Arabia

It has long been recognised that timely recognition of congenital hearing loss allows for the morbidity of hearing loss to be minimised. Due to the difficulties with identifying hearing loss in babies, combined with readily available screening technologies, many countries...

Fifth Sense James Lind Alliance Priority Setting Partnership for smell and taste disorders

Research priorities in the past have been dominated by the quixotic curiosity of individual academics and the capricious generosity of funding organisations. There must be a better way... At Fifth Sense, research is fundamental to the work we do. Above...

Cocaine-induced ENT pseudo-GPA (CIEpGPA): an underdiagnosed entity

Cocaine-induced ENT pseudo-GPA is increasingly seen in our ENT clinics. The authors of a new ENT UK guideline offer a concise overview for day-to-day recognition and management. Use of cocaine has steadily increased in Europe since 2010 and now represents...