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An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...
Submental island flap to reconstruct the lower lip
The lips are necessary for oral competence, cosmesis, speech and feeding. Non-melanoma cancers can affect the lips, and the lower lips are about 80% more likely to be affected. A large number of these cancers are squamous cell carcinomas. Treatment...
Cosmesis of the nose in cleft lip and palate
The cleft nose is one of the most challenging pathologies for rhinologists and facial plastic surgeons to address. The combination of architectural deformity (related to the extent of lip deformity) and scarring from previous surgery combine to cause the surgical...
The mark of the head and neck surgeon
Like Zorro, the head and neck surgeon leaves their mark. No more so than during parotid surgery. Various modifications have been put forward modifying the classic Blair incision. This latest modification camouflages the pre-tragal scar by running it on to...
Childhood bony facial tumours
This review article covering maxillary and mandibular tumours is from an edition of the Clinics covering paediatric head and neck masses from frequently encountered congenital malformations to the rarities. There is a wide differential diagnosis for childhood mandibular or maxillary...
One airway, one disease - not for everyone!
While 85% of asthmatic patients have rhinitis, only 20-30% with rhinitis have asthma. Together with atopic dermatitis (AD), rhinitis and asthma form a triad that tend to co-exist in patients (multimorbidity). This co-existence raises the possibility of genetic mechanism. Authors...
The future of biologics?
This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...
