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Prognostic value of neutrophil-to-lymphocyte ratio in HPV-positive oropharyngeal cancer
The authors propose that high neutrophil-to-lymphocyte ratio (NLR) is associated with poor disease-free survival (DFS) in patients with human papillomavirus positive (HPV+) oropharyngeal cancer (OPC). This is a retrospective study that compared the outcomes of 43 patients treated for HPV+...Leightons and The Hearing Care Partnership Opens Registration for Groundbreaking New Clinical Conference: Oxygen 2025
Leightons Opticians & Hearing Care is excited to announce that registration is now open for Oxygen 2025, a pioneering clinical conference taking place on the 9th and 10th of May 2025. This highly anticipated event, hosted by the leading independent,...
Active surveillance for papillary thyroid cancers – what is the risk of progression?
Papillary thyroid cancers (PTCs) are generally considered to be indolent malignancies with favourable outcomes. Active surveillance (AS) has consequently been trialled as a management option for small PTCs with no evidence of regional lymph node involvement, especially papillary thyroid microcarcinomas...
BPPV duration as a predictor for therapy
Benign paroxysmal positional vertigo (BPPV) is one of the most common vestibuar disorders encountered in the neurotology clinic. The majority of cases of BPPV are due to vestibuar lithiasis in the posterior semicircular canal, but there are reports of cases...Screening for hearing aid fittings – an approach for primary care
Introduction The communication difficulties related to hearing loss can lead to ‘depression, social withdrawal and problems with employment and access to information sources’ [1]. Furthermore, unmanaged hearing loss is associated with dementia, a poorer quality of life, depression, anxiety and...Mind the gap – developing a sustainable pipeline for hearing therapeutics
In this article, the authors describe three key challenges faced in developing hearing therapeutics. Collaboration between companies, sectors and disciplines will be key to finding solutions. The unmet need for therapies for hearing loss grows apace, with prevalence rising across...
Laryngeal disorders associated with HIV infection
Following the introduction, and now widespread availability, of combined antiretroviral therapy, HIV has become a chronic disease with minimal or indeed no negative impact on life expectancy. As a result, there is a growing public health interest in establishing the...Thyroid ultrasound elastography: does nodule stiffness predict malignancy?
Approximately 50% of the general population has a thyroid nodule while 5-15% of these are malignant [1]. A major challenge, therefore, is how to detect the malignant nodules for appropriate, timely treatment and avoid unnecessary, costly investigations for the remainder....Rotational chair testing: “To rotate, or not to rotate, that is the real question”
Passive whole body rotation tests are widely considered to be the ‘gold standard’ for the identification of bilateral peripheral vestibular disorders (bPVD), but also have a part to play in identifying unilateral disorders (uPVD). In this article Paul Radomskij discusses...Early detection pathways for congenital cytomegalovirus for infants referred from the newborn hearing screen
This article discusses requirements for an early congenital cytomegalovirus (cCMV) detection pathway to ensure children do not miss out on the opportunity for timely diagnosis and treatment. The pathways described are currently in use in England and apply to well...
Lymph node ratio in tongue cancer
This is an analysis of 88 patients treated in Switzerland between 2003 and 2012. All patients had a selective neck dissection and recurrence occurred in 25 patients. Overall and disease specific survival were 72% and 80%. They specifically looked at...
