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The hippo and the nose
Chronic rhinosinusitis with nasal polyps (CRSwNP) leads to histological changes including thickening of the basilar membrane and epithelial proliferation. Molecular mechanisms underlying these changes are still not fully clear. A signalling pathway called the hippo with Yes‐associated protein (YAP) as...
Imaging of the parathyroid glands in primary hyperparathyroidism: where do we stand?
Primary hyperparathyroidism (PHPT) refers to an intrinsic parathyroid gland abnormality that produces excessive secretion of parathyroid hormone. PHPT is diagnosed biochemically, and surgical excision of the abnormal parathyroid tissue represents the only definitive cure. Historically, the standard operative management of...
Diagnostic criteria for haemodynamic orthostatic dizziness
Over the past several years, the Bárány Society has been developing an International Classification of Vestibular Disorders (ICVD) in order to standardise diagnosis and nomenclature for both clinical and research purposes. Many in vestibular practice would be familiar with the...
The polyp shrinker
Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...
To montelukast or not to montelukast
Both histamine and cysteinyl leukotrienes play an important role in both seasonal allergic rhinoconjunctivitis (SARC) and asthma. A combination therapy against both was shown to give benefit both in vitro and in vivo. Authors wanted to test the efficacy of...
Laryngopharyngeal reflux - would mucolytics help?
With laryngopharyngeal reflux (LPR) being such a common presenting complaint to ENT clinics, who would not want to have more, effective treatment options for patients suffering with this annoying condition? In their small randomised, controlled trial, Chae et al put...
Do we need contrast MRI when screening for vestibular schwannoma?
Gadolinium contrast enhanced T1-weighted (gT1w) MRI images of the internal acoustic meati have long been considered the gold standard in the diagnosis of vestibular schwannoma (VS). However, the addition of contrast to the MRI examination increases the cost and time...
Semicircular canal dehiscence and cochlear implantation
Semicircular canal dehiscence (SCD) is thought to occur in 3% of the population, it is mostly asymptomatic, but patients may present with sound-induced vestibular symptoms, low-frequency conductive hearing loss, autophony, hyperacusis and aural fulness. With the increasing utilisation of cochlear...
Impact of vestibular rehabilitation on patients with peripheral vestibular disorders
Vestibular rehabilitation is a widely used treatment for vestibular dysfunction. It can improve dizziness, fall risk, balance, and emotional status. However, some patients do not get benefit from vestibular rehabilitation. In this study, the authors assessed the impact of dizziness...
Foretelling: post-stroke recovery of dysphagia is predicted by cognition
Around two thirds of people in the acute phase of stroke recovery will experience dysphagia. Up to six months following a stroke this may be present in 13-18% of cases. The degree of cognitive impairment seems to be associated with...
The ‘My Hearing Explained’ tool: audiologist and client perceptions
The study notes that the pure tone audiogram has been the primary clinical and counselling tool used by clinicians to assess and describe hearing thresholds to individuals and families since 1922. The Ida Institutes, ‘My Hearing Explained’ tool has become...
