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Laryngeal oedema as a side-effect of tyrosine kinase inhibitor therapy
Tyrosine kinase inhibitors (TKIs) such as Imatinib are increasingly being used to treat haematological and solid malignancies. These agents have revolutionised the treatment of chronic myeloid leukaemia in particular. Although better tolerated than most conventional chemotherapy drugs, multiple side-effects have...
What causes delays in head and neck cancer treatment?
This article identifies which factors are responsible for delays in cancer management by a retrospective case-control series study, statistically comparing two groups, each of 50 patients, one receiving timely treatment and the other breaching set targets. It was observed that...
Describing the most useful OSA assessment?
This article sets out to comprehensibly describe drug induced sleep endoscopy and its role in determining the level of obstruction in patients with OSA. The advantages described include the fact that other techniques, including Muller’s manoeuvre, have significant variation in...
Prioritisation of surgery for pituitary tumours
This study is based on the findings of internationally renowned skull base surgeons who convened to recommend this stratification scheme. The study authors report that incidental diagnosis of pituitary tumours during routine imaging as well as early identification of visual...
Graft material success for tympanoplasty
This retrospective Belgian study looked at the success rates of xenograft and human allograft materials as alternatives to more common autograft materials like fascia, fat or cartilage. A total of 71 consecutive patients who underwent type 1 tympanoplasty were included,...
Obstructive sleep apnoea: Does maxillomandibular advancement work?
This is a paper from the Netherlands reviewing 62 patients who underwent maxillomandibular advancement for moderate to severe obstructive sleep apnoea. The authors observed a 71% success rate with mean apnoea hypopnea index (AHI) reduction of 69%. There was no...
Risk factors for loco regional recurrence for oral SCC
Over 250,000 cases of oral squamous cell carcinomas are diagnosed annually worldwide with 128,000 registered deaths. The authors of this study are from a single institution in Germany and have conducted a retrospective audit of 517 patients with oral SCC...
A drug to prevent hearing loss caused by ototoxic therapeutics
This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...
Above and beyond interprofessional learning
There has been a significant focus on interprofessional education for all health professionals over recent years. The American Speech-Language-Hearing Association became a member of the Interprofessional Education Collaborative (IPEC) competencies (in America) in 2016. These competencies provide four core competencies...
Can junior doctors provide immediate help in airway and other ENT emergencies?
In the present trends for centralisation of ENT emergency services, availability of immediate middle grade or senior help in acute ENT emergencies does not always exist on site and hence the role of junior doctors in handling this is enhanced...
Safety of outpatient thyroid and parathyroid surgery
This study examined the safety and outcomes of matched groups of patients, undergoing either inpatient thyroid / parathyroid surgery or being discharged within eight hours of surgery. There were 2,362 patients in each group who were matched by a ‘propensity...
