This is a retrospective review from the Netherlands over a 20-year period to 2009 of squamous cell carcinoma (SCC) of the lip. In total, 979 cases of the lower lip were identified and 126 of the upper lip, with men being 2.6 times more often affected. The overall five year survival was 74%. The 10 year survival for patients with upper lip SCC was 94% compared to 90% for the lower lip. There was no survival difference for those treated by surgery alone. They unexpectedly found that upper lip patients were more frequently treated by surgery and less often by radiotherapy than lower lip patients, acknowledging that both are reported to be fully effective.