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Adjuvant radiotherapy for locally advanced (T3–4) major salivary gland cancer – survival benefits quantified

Complete surgical excision of major salivary gland cancers (MSGCs) is the current mainstay of curative treatment for this disease. Indications for postoperative radiotherapy according to current UK national guidelines include high-grade tumours, advanced-stage (stage 3–4) tumours, involved resection margins, perineural...

A new tool to enhance smell recovery?

Vericiguat is a soluble guanylate cyclase activator which boosts intracellular cGMP and promotes smooth muscle relaxation. It is approved for use in heart failure, but the authors hypothesise that it may also enhance neuronal olfactory signalling via cGMP elevation. Eighty-eight...

British Laryngological Association – Cutting Edge Laryngology 2024

It’s always good to know which conferences are the best for trainee experience. Here, Valerie Kim reveals why BLA Cutting Edge was so worthwhile. I had a wonderful time attending the British Laryngological Association (BLA) – Cutting Edge Laryngology Conference,...

OBITUARY: Remembering Thomas J Balkany 1948 - 2025

Helen Cullington, our Specialty Editor – Audiology (implantables), pays tribute to a pioneer. Back in 1996 – having worked as a cochlear implant audiologist for three years in the UK – I felt ready for a new challenge. I faxed(!)...

Oscar Wilde’s Final Irony

The celebrated writer and poet, Oscar Fingal O'Flahertie Wills Wilde was born on 16 October 1854 in Dublin. He distinguished himself as a classicist at Trinity College Dublin before, earning a scholarship to Oxford University, where he gained a double...

Will it ever happen?

Audiology is a rapidly evolving field, with many exciting developments on the horizon. David Baguley identified some topics of interest, and asked some international experts ‘will it ever happen?’ Gene therapy for deafness After years of development, gene therapy for...

Advances in laryngeal surgery

We are seeing many advances in laryngology: from the lab, from equipment manufacturers and from developments in surgical techniques. The field of laryngology has been under constant change in recent years, with the introduction of new technologies and research. The...

Rhinoplasty for cleft nose deformity

Modern cleft lip and palate repairs produce excellent functional and aesthetic results at an early age. Tony Holmes, a craniofacial surgeon with over 40 years’ experience, shares his wisdom on the best timing and techniques for addressing the associated complex...

Endoscopic CSF leak repair using nasoseptal flap

Many of us during training or in established practice will have encountered the complication of anterior skull base CSF leak. This can be a challenging problem to deal with and in this article the authors describe their favoured approach. Cerebrospinal...

Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours

Introduction Cancer cases continue to increase worldwide, and­­ head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...

Wearable tech revolutionising sleep monitoring: a new era in sleep health

Restful sleep is crucial for health but conditions like obstructive sleep apnoea (OSA) can significantly disrupt it, leading to fatigue, cardiovascular issues, and other serious health problems. Polysomnography (PSG) remains the gold standard for OSA diagnosis [1], however it is...

Cochlear implants and therapeutics: a natural partnership?

Global awareness of cochlear implants as a solution for hearing loss is slowly increasing and gaining acceptance. The potential for combining cochlear implants with inner ear therapeutics is immense, with promise in several areas. This article takes us on a...