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Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
One airway, one disease - not for everyone!
While 85% of asthmatic patients have rhinitis, only 20-30% with rhinitis have asthma. Together with atopic dermatitis (AD), rhinitis and asthma form a triad that tend to co-exist in patients (multimorbidity). This co-existence raises the possibility of genetic mechanism. Authors...Endolymphatic sac surgery: controversial procedure for the treatment of Ménière’s disease
Landmark Paper: Thomsen J, Bretlau P, Tos M, Johnsen NJ. Ménière’s disease: endolymphatic sac decompression compared with sham (placebo) decompression. Ann N Y Acad Sci 1981;374:820-30. Of all of the chapters in the Landmark Papers book, the chapter that discussed...
Can amplification preserve auditory function?
Hearing loss is a noted modifiable risk factor for dementia, and is also associated with depression, decreased quality of life and isolation. Hearing aids are the main intervention for presbycusis and a 2017 Cochrane Review showed that they have a...Patient experience of necrotising otitis externa
Necrotising otitis externa is increasing in incidence in the UK and becoming a rising burden to patients and health services. Despite a growing body of literature on this condition, we know very little about patient experience of necrotising otitis externa....
Evidence based guidelines for ONS treatment in occipital neuralgia
Occipital neuralgia (ON) can flummox otolaryngologists especially when it follows mastoid surgery. The paroxysms of sharp, electrical pain originating from the occiput can extend along the posterior aspect of the scalp and even up to the mastoid. Although the aetiology...Cochlear implantation for single-sided deafness and asymmetric hearing loss
Continuing our sub-theme of cochlear implantation candidacy, Richard Irving and Raghu Kumar review the principles and benefits of cochlear implantation in individuals who have an asymmetric hearing loss. It is well known that cochlear implantation improves auditory capacity, and in...Audiological evaluation and management of teenagers with tinnitus
There is a growing interest in investigating, understanding and managing tinnitus in children and adolescents, with several articles on the subject published in journals over the last year. Brian Fligor describes the approaches to consider when discussing tinnitus with teenagers....
Sarcopenia and dysphagia in older community-dwelling adults
The prevalence of dysphagia in community-dwelling older adults is reported to be around 15%. Outside of common neurological causes such as stroke, Parkinson’s disease and dementia, recent studies have suggested that sarcopenia may be an independent risk factor for the...
Predicting the need for salvage laryngectomy
The treatment of laryngeal cancer has seen a shift towards organ preservation strategies with non-surgical treatment offering equivalent survival outcomes. Nonetheless, salvage total laryngectomy (SLT) remains an important curative management option in cases of treatment failure or recurrence. The authors...The workplace environment and doctors’ health (ENT)
It is well established that doctors have higher levels of stress, depression and suicide than the general population [1] and most other professional groups (Figure 1 illustrates the factors that can make us ill). In addition they have high levels...
