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Follicle stimulating hormone receptors; an aid for the pathologist?
It is well known that Follicle Stimulating Hormone receptors (FSHRs) are found in extra-gonadal tumours such as those within thyroid tissue. This Polish study analysed 44 thyroid resection specimens to look for the presence of these receptors. No mention is...
Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
One airway, one disease - not for everyone!
While 85% of asthmatic patients have rhinitis, only 20-30% with rhinitis have asthma. Together with atopic dermatitis (AD), rhinitis and asthma form a triad that tend to co-exist in patients (multimorbidity). This co-existence raises the possibility of genetic mechanism. Authors...Questionnaires to measure tinnitus severity
The handicap associated with tinnitus can arise from any combination of stress, anxiety, depression, emotional distress, insomnia, difficulties concentrating, or impairments in quality of life or everyday functioning. Measuring such handicap and determining clinical need is therefore far from trivial....By the people, for the people: a multidisciplinary facial nerve clinic with a difference
Facial nerve palsy is regularly seen in ENT clinics. Underlying diagnoses are excluded, and the patient is often then discharged to ‘see how it goes’, with or without an ophthalmology referral. Here, Catherine Meller describes how she and her team...From trauma to recovery: treatment at Defence Medical Rehabilitation Centre
This year (2014) is the centenary year of the beginning of the Great War. This conflict brought with it a cluster of emotional disorders that were called at the time, Shell-Shock. The present conflict in Afghanistan has been talked of...
Can amplification preserve auditory function?
Hearing loss is a noted modifiable risk factor for dementia, and is also associated with depression, decreased quality of life and isolation. Hearing aids are the main intervention for presbycusis and a 2017 Cochrane Review showed that they have a...Patient experience of necrotising otitis externa
Necrotising otitis externa is increasing in incidence in the UK and becoming a rising burden to patients and health services. Despite a growing body of literature on this condition, we know very little about patient experience of necrotising otitis externa....Endolymphatic sac surgery: controversial procedure for the treatment of Ménière’s disease
Landmark Paper: Thomsen J, Bretlau P, Tos M, Johnsen NJ. Ménière’s disease: endolymphatic sac decompression compared with sham (placebo) decompression. Ann N Y Acad Sci 1981;374:820-30. Of all of the chapters in the Landmark Papers book, the chapter that discussed...
Sarcopenia and dysphagia in older community-dwelling adults
The prevalence of dysphagia in community-dwelling older adults is reported to be around 15%. Outside of common neurological causes such as stroke, Parkinson’s disease and dementia, recent studies have suggested that sarcopenia may be an independent risk factor for the...
Predicting the need for salvage laryngectomy
The treatment of laryngeal cancer has seen a shift towards organ preservation strategies with non-surgical treatment offering equivalent survival outcomes. Nonetheless, salvage total laryngectomy (SLT) remains an important curative management option in cases of treatment failure or recurrence. The authors...
