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Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...
Virtual vestibular rehabilitation (VR) is as effective as in-person VR
The effectiveness of vestibular rehabilitation (VR) for patients with several vestibular disorders is well established. Access for in-person clinic-based VR is however patchy and limited. To widen access, offering VR via virtual platforms is increasingly being adopted. The authors conducted...
Magnetic resonance imaging (MRI) head without general anesthesia in children
‘Physician heal thyself’: this biblical proverb has an increasing importance in modern healthcare systems, especially when we consider the rising incidence of physical and mental burnout amongst all staff. Musculoskeletal disorders are increasing – according to the Work-Related Musculoskeletal Disorders...
Review of surgical treatments of intractable Meniere’s disease
This is a nice summary of the evidence available for the surgical treatments for intractable Meniere’s disease. To summarise, in five-10 years, over 90% of vestibular neurectomy cases, more than 80% of intratympanic gentamycin treatment, and 70-80% of endolymphatic sac...What’s new in auditory processing?
Auditory processing disorder (APD) has had a controversial history, stemming mainly from lack of scientific rigor and accepted clinical definition. That situation is now changing. Driven by the huge number of people with unaddressed listening difficulties, basic discoveries in neuroscience,...The ups and downs of overseas research – the inner ear at altitude
Conducting research at extreme altitude presents unique challenges. This study of the inner ear at 5350m navigates setbacks in a quest for scientific discovery. Having completed a diploma in mountain medicine in my foundation years, I decided to undertake a...Reducing hierarchy for individuals and teams across ENT
Alexander Pope said that “to err is human”, but medical errors can have serious consequences. How can better communication minimise the risk of them occurring in the first place? Allowing all members of the surgical team to feel empowered to...In conversation with Catherine Rennie
Miss Catherine Rennie has recently been recognised as one of the Women’s Engineering Society’s (WES) Top 50 Women in Engineering 2021. According to WES, these awards celebrate the “best, brightest and bravest women in engineering, who recognise a problem, then...Staphylococcus aureus as a cause of refractory chronic rhinosinusitis
Staphylococcus aureus has long been linked to chronic rhinosinusitis, particularly recalcitrant cases. In this article, Alkis Psaltis describes how newer techniques have shown higher rates of S. aureus infection than were previously thought, and explains how the bacteria are able...
Novel wax solvent
This paper describes an open label, prospective study undertaken by the authors to demonstrate the safety and efficacy of a novel topical wax solvent. This new product has a dual action using a bicarbonate system to disrupt the esters and...
IL-25 and nasal polyps, another target
Immune response in chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly via type 2 T-helper (Th2) cells while Th1 cells characterise chronic rhinosinusitis without nasal polyps (CRSsNP) immune response. CRSwNP is heterogeneous on a cytological level causing a varied response...
