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Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...
Coblation for lingual haemangiomas
Haemangiomas are benign vascular tumours characterised histologically by a marked proliferation of blood vessels. They can be either congenital or acquired, and can affect the tongue, both within the oral cavity and the oropharynx. A variety of interventions exist for...
Talking to the animals
People with communication difficulties have an increased risk of mood and anxiety disorders. This often means that speech and language therapists must actively engage in counselling as part of their intervention. It is not surprising, therefore, that the active components...
Exciting advances in facial reanimation
Despite several techniques for reanimation after facial paralysis, the management of these patients continues to challenge us. This paper reviews advances in facial reanimation surgery, provides updates on the timing of intervention, modifications to the traditional gracilis muscle transfer, other...
Going online with dysphagia practice: potential for innovation post pandemic
Telepractice is perhaps the most widespread service innovation to have received such rapid uptake across health systems globally. Disciplines that started to adopt telehealth prior to the pandemic found themselves at the forefront of a seismic shift to delivering healthcare...
The future of biologics?
This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...
Painful temporomandibular joints
This paper is a meta-analysis of randomised controlled trials comparing arthrocentesis with conservative management in painful and restricted mouth opening temporomandibular joint symptoms. Temporomandibular joint dysfunction comprises a spectrum of disorders commonly involving facial pain and loss of oral function...
Put the maxilla in the right place
This is a paper from Singapore where they attempted to validate the position of the maxilla in the sagittal plane against several reference lines arising from the position of the forehead in orthognathic surgery. The position of the maxilla was...
Dysphagia services in the emergency department
The emergency department acts as the first port of call for many individuals with wide-ranging diagnoses and conditions, several of whom may potentially present with dysphagia. It is not a usual environment in which speech and language therapists regularly work,...
Expectations and practice
Reading this paper is reassuring. It does not appear to be groundbreaking in its results but research can be as useful, if not more so, when it consolidates knowledge and helps unify the research base. This paper focuses on those...
How common is dysphagia in people with sarcopenia?
Sarcopenia, the progressive loss of muscle mass and function, affects about 10–16% of the global elderly population. The condition has also gained increased attention recently as a contributing factor to dysphagia amongst older individuals. The authors of this paper undertook...
