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Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...
Long-term results for dupilumab are very promising!
Eosinophilic chronic rhinosinusitis (eCRS) is complicated by frequent early and aggressive recurrence of polyps after both medical and surgical treatment regimes. Dupilumab is an anti-IL-4/IL-3 receptor monoclonal antibody and has been previously studied in the SINUS-52 study, with an observation...
A useful adjuvant treatment for SNAC or IP
5-Fluorouracil (5FU) is a topical preparation used in the treatment of various dermatological, ocular and gynaecologic malignant and pre-malignant conditions, and this literature review looks at the efficacy of 5FU in treating inverted papilloma and sinonasal tumours. The authors cite...The common frontal sinusotomy (Lothrop) and chronic rhinosinusitis
As our understanding of the pathophysiology of CRS evolves, so do our treatment strategies. It is accepted that in many cases, the main role of surgery is to allow better penetration of topical therapies to the sinus cavities. What, then,...In conversation with Catherine Rennie
Miss Catherine Rennie has recently been recognised as one of the Women’s Engineering Society’s (WES) Top 50 Women in Engineering 2021. According to WES, these awards celebrate the “best, brightest and bravest women in engineering, who recognise a problem, then...Building sound: from Stonehenge to a Symphony Hall
Modern architecture can use scientific techniques to shape room acoustics and create great sounding places. Professor Trevor Cox discusses our ancestors’ understanding of the importance of building techniques to enhance acoustics from Stonehenge to a Symphony Hall. Going to an...Armageddon and surgical outcomes
In the excitement of the festive season I am sure many of you will have omitted to commemorate the 60th anniversary of a highly significant world event. According to a small apocalyptic cult led by a Chicago housewife named Dorothy...
