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Harnessing head and neck cancer genomics for personalised medicine

Luc Morris updates us on the future of cancer diagnosis and treatment, which lies in “personalised oncology”, where specific molecular alterations of each tumour will be identified, and matched with actionable alterations in existing therapies, ushering in the era of...

Red flags in the development of childhood speech and language

Problems of speech and language in early childhood can influence a child’s emotional development, academic prowess and quality of life. This article is a consensus report from the Netherlands describing 124 clinical signs and 34 red flags of atypical speech...

Medication and its effect on the larynx

This article summarises different medications and their effect on the voice. A growing number of patients we see in clinic are on multiple medications that could affect vocal cord function. The author summarises different classes of medications and their potential...

Role of intranasal steroids after radiotherapy for nasopharyngeal carcinoma

Rhinosinusitis often follows radiotherapy in the treatment of carcinoma of the nasopharynx. The interval and severity may vary with the dose of radiation and stage of the carcinoma. In this randomised, controlled study, patients who developed rhinosinusitis after radiotherapy treatment...

A therapeutic algorithm for tracheoesophageal periprosthetic leakage

Tracheoesophageal voice prosthesis leakage can be intravalvular (more common) or periprosthetic (focus of this study). The authors studied the causes of periprosthetic leakage among 115 patients attending for voice prosthesis management (1374 clinic attendances) treated between December 2014 to December...

New curricula: trainees’ and trainers’ thoughts

After the disruption to training and clinical practice from COVID, it is interesting and perhaps encouraging that plans are in place to support ENT training in both mainland Europe and the UK with new formal curricula. We hear trainees’ and...

Deep space neck infections – salivary gland as source is commoner in elderly patients

Whilst deep space neck infections (DNI) can originate from many sources, dental and salivary glands are commonly the culprit. This paper details 44 patients treated for deep space neck infections originating from salivary gland and compares them to a previously...

Do certain chronic medications increase dysphagia in older people?

Oropharyngeal dysphagia is known to affect a high number of older people in the community, in care homes and in acute geriatric admissions to hospital. The authors of this study have recognised that many older people take drugs for chronic...

Identifying CN IX and X using endotracheal tube electrodes

This clinical study describes the possible usefulness of endotracheal tube electrodes in monitoring vocal cord function during cerebellopontine angle surgery in 20 patients. Lower cranial nerves, especially IX and X are at risk of injury during skull base surgery although...

Spirituality and tinnitus – blocking out the haters!

The brain is fantastic at blocking out unwanted noise. Place a microphone on your temporal bone and you’ll realise you are subject to a relentless bombardment of sound you’ll never consciously hear: the clicking of your temporomandibular joint, the pulsating...

Eosinophilic complications during dupilumab therapy

Dupilumab is a humanised monoclonal antibody that targets type 2 inflammation by blocking IL-4 and IL-13 signalling. Reported adverse events from its use include injection site erythema, conjunctivitis, arthralgia and hypereosinophilia. The potential for more severe eosinophilic-related complications such as...

Discovery in the genetics of complex disease: Otitis media

Otitis media (OM), a common disease of childhood, is considered to be a complex trait with multiple genetic and environmental factors expected to contribute to a child’s risk of developing recurrent acute OM (rAOM; ≥3 episodes in 6 months or...