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Immunosuppresants and ototoxicity
There is a wide range of immunosuppressant drugs ranging from calcineurin inhibitors (e.g. cyclosporine), anti-folic agents (e.g. methotrexate) to anti-TNF and monoclonal antibodies, many of which could be ototoxic. The authors performed a systematic review assessing ototoxicity secondary to immunosuppressant...
Is a hemithyroidectomy as effective as a total thyroidectomy for compressive symptoms?
The claim made in the title of this paper, that hemithyroidectomy is equally as successful as total thyroidectomy in alleviating compressive symptoms from goitres, is certainly intriguing. And with the inclusion of 45,539 subjects, it would at first glance seem...
Measuring radiation fibrosis in patients with head and neck cancer
People treated with radiotherapy for head and neck cancer experience several acute and chronic effects of this treatment, of which fibrosis is perhaps the most common. Fibrosis occurs as a wound healing response and leads to scarring and reduced range...
A new tool to enhance smell recovery?
Vericiguat is a soluble guanylate cyclase activator which boosts intracellular cGMP and promotes smooth muscle relaxation. It is approved for use in heart failure, but the authors hypothesise that it may also enhance neuronal olfactory signalling via cGMP elevation. Eighty-eight...Global alliance brings hearing care to people in 14 developing countries
To mark World Hearing Day, a global project has been created to provide access to ear and hearing care services for thousands of people living with undiagnosed and untreated hearing loss.
