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Dysphagia in people with HPV-related oropharyngeal cancer
Human papilloma virus (HPV) associated oropharyngeal cancers are becoming much more prevalent and, in some geographic areas, have overtaken tobacco as the leading cause of oropharyngeal cancer. HPV-associated cancers are also reported to have better prognosis in general, and research...
Immunosuppresants and ototoxicity
There is a wide range of immunosuppressant drugs ranging from calcineurin inhibitors (e.g. cyclosporine), anti-folic agents (e.g. methotrexate) to anti-TNF and monoclonal antibodies, many of which could be ototoxic. The authors performed a systematic review assessing ototoxicity secondary to immunosuppressant...
Role of maxillary sinus irrigation as an adjuvant to current management of chronic rhinusitis without polyposis
Several decades have passed since irrigation of maxillary sinuses generally became a treatment of the past. A more recent concept of biofilms may have evoked new interest in this past procedure, fraught with its own issues. In this study, the...
Early results of the Cochlear Osia (active transcutaneous bone-conduction implant) in teenagers
This funded research trial involving 14 adolescents, aged 10 to 17 years, in the Toronto Hospital for Sick Kids was carried out just prior to the new Osia implant obtaining FDA approval for use in the USA. The majority had...
Take a breath between mouthfuls
Pulse oximetry provides a measure of the percentage of oxygen in the blood. The usual range of readings on pulse oximetry is 97-99%. Older people may have lower pulse oximetry readings than younger people, and young women have higher readings...
Does pollution worsen inflammatory nasal problems?
This ambitious study, conducted over a period of four years, assessed 27,863 patients and compared levels of allergic rhinitis (AR) or chronic rhinosinusitis (CRS) with the levels of air pollution recorded, as assessed by levels of particulate matter (PM10). They...
Strength of evidence in otolaryngology research – do women make the difference?
Clinicians around the world understand the need for research and publication of gathered evidence to inform practice and improve patient outcomes. The introduction of the Oxford Centre for Evidence-based Medicine (CEBM) Levels of Evidence guideline in 2011, has been invaluable...
Gadolinium enhanced MRI and the diagnosis of Ménière’s disease
Despite various criteria applied over the years to diagnose Ménière’s disease since the concept of endolymphatic hydrops was first observed in postmortem examinations of patients in 1938, the diagnosis still remains mainly clinical. To visualise endolymphatic hydrops in MRI imaging,...
Hearing preservation in CI, any predictors?
The electrically evoked compound action potential (eCAP), obtained non-invasively from cochlear implant (CI) recipients, represents a population response of the auditory nerve to electrical stimulation. The eCAP characteristics include threshold (the lower the better), growth of response (the steeper the...
Recurrent facial palsy
Recurrent facial palsy is relatively rare, and its clinical features are not well known. The authors set out to investigate this further by undertaking a retrospective study of patients with recurrent facial palsy over a 14-year period. Only Bell’s palsy...
A time-saving method for faster cancer diagnosis and treatment
One of the main impediments in achieving UK Government cancer diagnosis and treatment targets is lack of diagnostic capacity. An increase in head and neck cancers by 50% in the last five years has put on additional strain. In this...
