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Malignant transformation of leukoplakia in previous cancer patients

This is a retrospective study from Taiwan assessing risk factors in developing oral squamous cell carcinoma from surgically excised oral leukoplakia in patients with a previous oral cancer, the underlying thought being that patients with an oral carcinoma have a...

The future of biologics?

This paper takes a deep dive into how eosinophilia affects the responsiveness of the host to the two monoclonal antibodies mepolizumab and bendralizumab, both of which are active against IL5. We know that eosinophils are attracted and trapped into the...

Sinonasal undifferentiated carcinoma – slowly getting there

The rarest of the rare, sinonasal tumours form only a small part of the total number of head and neck tumours and undifferentiated carcinoma (SNUC) is one of the rarest of this group. There is some data (and some expert...

Head and neck radiation and the brain

An increasing number of patients with head and neck squamous cell carcinoma and other lesions are treated with high dose radiotherapy. An increase in survival rates is being reported along with a younger patient demographic. The long-term effects of treatment...

Delirium post-op

This is a retrospective study from Japan analysing 102 patients who underwent oral cancer resection and free flap reconstruction. Postoperative delirium occurred in a third of these patients. An increased risk was identified in those with high preoperative albumin, postoperative...

Association of childhood OME with obesity

Many factors influence the development of otitis media with effusion (OME) in children, some of them being increased plasminogen factor inhibitor (PAI-1) levels, eustachian tube obstruction and gastro-oesophageal reflux. These factors are also associated with obesity. Sixty children with mean...

Predicting postoperative respiratory complications following paediatric adenotonsillectomy

This systematic review aimed to compare the presence of clinical features versus the polysomnography results in predicting major postoperative respiratory complications in children undergoing adenotonsillectomy for OSA. The study was prepared according to the PRISMA checklist. Overall 22 studies met...

Single sided deafness and cochlear implants

Cochlear implants (CI) can restore hearing in the profoundly deaf ear. Risk/ benefit and cost considerations dictate strict criteria that must be met for patients to be eligible. People with single-sided deafness are not eligible to receive a cochlear implant...

Patient-related factors that require revision surgery for otosclerosis

Stapes surgery for otosclerosis has a high success and low complication rate but, over a period of time, good results can deteriorate, requiring revision surgery. In this study, the authors have focused on patients’ demographic data as predictive factors for...

Sellar surgery – when to prepare for repair

Endoscopic sellar surgery, especially for adenomas, is a relatively safe, straightforward surgery with (mostly) reproducible results and few complications. One of the commonest complications is the creation of a CSF leak with the subsequent need for repair (there is usually...

Blood type and epistaxis

In this Turkish study, the authors attempted to determine if there was an association between ABO blood type and epistaxis. They looked at 359 epistaxis admissions at the same hospital over a three-year period. Only patients with idiopathic epistaxis were...

Which technique is better for cholesteatoma surgery?

There continues to be debate over the benefits and limitations of different techniques for cholesteatoma surgery. This retrospective review of 132 cases over a 10 year period with primary cholesteatoma from Turkey tried to establish which technique [canal wall up...