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An algorithm to distinguish between distant metastases and metachronous lung primary in patients with HPV-related oropharyngeal cancer
Distinguishing between distant metastases of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) and metachronous primary lung squamous cell carcinoma (SCC) is important as it has implications for treatment, prognosis counselling, and registry data. Although p16 immunohistochemistry (p16 IHC) is widely accepted...
Dysphagia in people with HPV-related oropharyngeal cancer
Human papilloma virus (HPV) associated oropharyngeal cancers are becoming much more prevalent and, in some geographic areas, have overtaken tobacco as the leading cause of oropharyngeal cancer. HPV-associated cancers are also reported to have better prognosis in general, and research...Gastric inlet patch – an under-diagnosed cause of globus
A gastric inlet patch (GIP) is an island of heterotopic gastric mucosa found commonly in the proximal oesophagus just below the upper oesophageal sphincter. It is often underdiagnosed due to its location. Its importance and clinical relevance can be underestimated...Neurological idiopathic disease: a shared journey for NASA and medicine
Whilst Southampton can’t really be described as an extreme environment, experiments carried out in the city have certainly been taken out of this world. Robert Marchbanks discusses one of the associations between Southampton, The International Space Station and tympanic membrane...Taking a fresh look at otoacoustic emissions
So what has changed in four decades of OAEs? Do we now have all the answers? Have we reached our optimum recording ability? Professor Kemp explains what we know, what we don’t know and what’s to come. In the 40...
Reliability of modified Dix-Hallpike test
Modifications of the Dix-Hallpike (DH) are sometimes necessary when the traditional DH is not feasible. The absence of any formal studies on modified DH was the idea behind this multicentre (three academic centres), prospective, randomised, single blinded and controlled clinical...
Better conversations for children with Autism and peers for now and for their futures
There are around 700,000 people with diagnosed Autism Spectrum Disorder (ASD) in the UK, according to 2011 census figures. A key diagnostic feature in ASD are difficulties in social interactions and conversations, social-emotional responses and relationships. The authors of this...
Persistent dysphonia due to cricothyroid muscle dystonia – should we be requesting laryngeal EMGs for non-resolving ‘functional’ dysphonia?
This article is an interesting report of a case of persistent voice problems affecting a 43-year-old physician that significantly compromised her ability to converse and communicate at work. Specifically, she had a fluctuating voice quality that would ‘choke off’, combined...Paediatric obstructive sleep apnoea
As tonsillectomy rates for recurrent sore throats have declined, there has been increasing recognition of the importance of OSA in children. Not always diagnosed early – or in some cases at all – and with continuing debate as to how...
Rapid Audiogram Interpretation: A Clinician’s Manual
This book is a manual and a workbook to systematically understand and interpret an audiogram for those who are new to audiometry such as residents, trainees and students. It is a worthy reference guide even to well-established practising clinicians. The...
Serum biomarkers for CRSwNP
This cross-sectional comparative study looked at 50 patients with nasal polyps who, at the time of diagnosis, also had a blood test evaluating serum total IgE, IL-17 and Pentraxin-3. The study assesses whether these blood markers are useful in the...
