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Harnessing head and neck cancer genomics for personalised medicine

Luc Morris updates us on the future of cancer diagnosis and treatment, which lies in “personalised oncology”, where specific molecular alterations of each tumour will be identified, and matched with actionable alterations in existing therapies, ushering in the era of...

Database WG2. The Tinnitus Patient Database in the TINNET COST Action BM1306

Berthold Langguth describes an innovative project that is creating the world’s largest multi-national patient database containing standardised information on tinnitus and medical history, otological examination and psycho-acoustic measures of tinnitus. A challenge for tinnitus treatment and tinnitus research is the...

Targeted focal parathyroidectomy

Leanne Hamilton and Louise Clark describe their technique for helping to localise parathyoid adenomas. Surgically this can be difficult, so careful preoperative evaluation using imaging as described can help minimise difficulties intraoperatively when identifying the parathyroid adenoma. Preoperative imaging has...

Contralateral OAEs in children

Several studies indicate that small changes in the medial olivocochlear (MOC) reflex may possibly be associated with certain pathologies. This could be measured by using contralateral acoustic stimulation (CAS) and observing suppression in otoacoustic emissions (OEAs). The main aim of...

Macrolinguistic assessment in early Alzheimer’s disease

Deficits in language production like word finding difficulty, and lexical-sematic impairment have been documented early in the course of Alzheimer’s disease (AD). According to the authors, the current language assessment methods used in AD patients do not account for macrolinguistic...

Day case orthognathic surgery

This paper analyses whether patient safety is maintained when orthognathic surgery is performed as an outpatient. This Swedish paper reviewed 165 patients, 107 of whom were to have what was termed outpatient care, and of which 101 (94%) were able...

Healthcare economics and device approvals

We use several FDA-approved devices in our clinical practice but are rarely aware about the stringent procedures followed by manufacturers, as well as the FDA, before the devices become commercially available. The authors of this paper undertook a comprehensive review...

Auditory brainstem response patterns are neural signatures

Through examples, this article describes how particular aspects of auditory brainstem responses can portray certain kinds of language or communication impairments – a characteristic pattern or ‘neural signature’. A reduction in processing of the fundamental frequency is seen commonly in...

Preoperative tumour embolisation

This review article analyses the role of preoperative endovascular tumour embolisation in the treatment of a variety of hypervascular head and neck lesions including juvenile nasal angiofibroma, glomus tumour, carotid body tumours, and meningioma. Although the concept of tumour embolisation...

The development of endoscopic sinus surgery – a meeting of three great minds

The story of the development of endoscopic sinus surgery is inextricably linked with the names of Stammberger, Messerklinger and Storz. Karl Storz’s daughter, Sybill Storz, tells us more. We would like to take this opportunity to express our appreciation of...

ENT and evidence-based medicine: How do they benefit each other?

How do we assess evidence, and how should ENT surgeons use EBM? Evidence-based medicine (EBM) is the practice of medicine based upon high quality scientific research. There are several formal definitions of EBM, the most widely quoted being that of...

Neurological idiopathic disease: a shared journey for NASA and medicine

Whilst Southampton can’t really be described as an extreme environment, experiments carried out in the city have certainly been taken out of this world. Robert Marchbanks discusses one of the associations between Southampton, The International Space Station and tympanic membrane...