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Pre-clinical development of magnetic delivery of therapy to middle and inner ears

Why are we developing this technology? A key problem in drug delivery is getting the therapy to the right place in the body, which is especially challenging for targets that are small, deep and are protected or surrounded by anatomical...

Developing an Innovation for ENT – from Idea to Market: how ‘e-i’ did it

Background endoscope-i (e-i) Ltd was incorporated into Companies House on December 3rd, 2012 following eight months of developing our first project, a simple iPhone adapter for endoscopes. Of the three founding shareholders, two are ENT surgeons and one a lecturer...

Imaging in hyperparathyroidism

Following their caudal migration at eight weeks of development, the parathyroid glands normally locate posterolaterally to the upper pole of the thyroid gland at the level of the cricoid cartilage (superior parathyroid glands arising from the fourth branchial pouch and...

Nuclear heads – and necks

Imaging of the extra-cranial head and neck is challenging due to the anatomic complexity of the region. CT, MRI and ultrasonography (US) are amongst the most frequently utilised radiological modalities in head and neck imaging but do not always provide...

Imaging and management of head and neck vascular anomalies

Vascular anomalies are a diffuse spectrum of abnormalities which often involve the head, neck and oral cavity. They are frequently misnamed, often being generically labelled as haemangiomas. This lack of basic understanding can cause confusion leading to a cascade of...

Effects of blast and acoustic trauma: assessment of hearing status on war veterans

Introduction Acoustical conditions of the military are often dangerous and there is a real risk of blast trauma and acoustic trauma [1, 2]. Levels of military noises maybe reach up to 125 dBA [3]. Weapons produce instant shock waves (10μs)...

Genetic discovery using animal models: presbyacusis

By their very nature, late-onset hereditary disorders offer a large window of opportunity for therapeutic intervention. However, before we can begin to think about strategies we need knowledge of the genetics and pathology underlying the condition. In this article we...

TORS for patients with sleep-disordered breathing

Transoral robotic surgery is now a well-accepted technique in malignant tumours of the tongue base. Here the team from St Mary’s and the Royal National Throat Nose & Ear Hospital in London describe its use in carefully selected patients with...

Chronic cough hypersensitivity syndrome

We all have patients who give us a ‘heartsink’ feeling; for many of us, the coughing patient is exactly such a situation. In this overview, Bhaskar Ram and Sangeeta Maini outline their approach to diagnosis. Declan Costello, Editor. Introduction Chronic...

History of photography in otorhinolaryngology in the 19th Century

In this final article of the History of ENT edition, João Clode introduces us to the history of medical photography in the 19th century, giving us some fascinating early examples of otorhinolaryngology photographs. Medical photography – the early years The...

The changing spectrum of cancer of the oropharynx: dilemmas and future directions

The association of HPV in oropharyngeal cancer has identified a ‘new disease’, with its unique biologic behaviour, and challenges for clinicians in selecting therapeutic combinations offering maximum efficacy and minimum morbidity or long-term sequela currently under study in clinical trials....