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Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours
Introduction Cancer cases continue to increase worldwide, and head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...Biologic therapies for chronic rhinosinusitis with nasal polyps: a new paradigm
Surgery for nasal polyposis has evolved significantly in the last 30 years, and now the medical management may be on the cusp of a revolution. Biologics using monoclonal antibodies to target specific immune pathways have introduced a paradigm shift in...The James Lind Alliance – involving patients and their health professionals jointly in setting priorities for research
In a world of patient-reported outcomes and patient-centred care, patient-centred research must also be considered. That is where the James Lind Alliance (JLA) comes in, as Caroline Whiting explains below. Through Priority Setting Partnerships (PSPs), it allows patients, their carers...Good Vibrations Day celebrates bone conduction
Swedish audiology and sound-processing company Oticon Medical has just celebrated its fourth Good Vibrations Day.
Is Dymista® useful for paediatric allergic rhinitis?
Allergic rhinitis (AR) affects up to 14.6% of the paediatric population. Whilst a recent Cochrane review has considered the evidence for intranasal corticosteroids as `weak and unreliable’ in paediatric AR, this product is a novel formulation combining Fluticasone and Azelastine...
Is surgery in obese children with obstructive sleep apnoea effective?
The authors present the results of their literature review and meta-analysis of studies examining adenotonsillectomy, uvulopalatopharyngoplasty (UPPP), supraglottoplasty, tongue base surgery or a combination in obese children with obstructive sleep apnoea (OSA). The one study investigating effects of UPPP was...
Complications associated with intra-tympanic steroid injections for sudden sensorineural hearing loss
Around 15,000 people in the UK experience a sudden sensorineural hearing loss (SSNHL) each year, and in the majority of cases the cause is unknown. Treatment options for idiopathic SSNHL include various modalities of steroid treatments which have known limitations...
Biologics for deafness
Cochlear implants and hearing aids are inherently limited in their ability to restore ‘natural’ hearing. Biological therapy to treat inner ear pathology still is evolving rapidly with several ongoing clinical trials, though none are available for clinical practice to date....
Outcomes of larger glottic cancer volumes treated with radiotherapy
T3 glottic cancer is characterised as vocal cord fixation and/or invasion into pre-epiglottic, post-cricoid, paraglottic spaces and/or within the inner cortex of thyroid cartilage. Traditionally, laryngectomy was considered the primary option to treat T3 laryngeal glottic cancers until other options...
Surgery plus radiotherapy keeps the helical keloid scar away
Keloid scars lead to significant psychological and cosmetic morbidity. As the pinna is a key component of facial cosmesis, pinna keloid scar formation can be aesthetically displeasing. Their stubbornness and high recurrence rate can be challenging to treat. This department,...
Epley manoeuvre angles
Posterior canal benign paroxysmal positional vertigo (PC-BPPV) is a common vestibular cause of dizziness regularly encountered in the outpatient clinic. The condition is often diagnosed with a positive Dix-Hallpike manoeuvre (DHM) – turning the patient’s head 45 degrees to the...
