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Interleukins, cilia and polyps

Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...

Sham controlled trial: BPPV

I was drawn to this study and it proved an enlightening read; it also is a good example of where recommendations of a Cochrane review for long-term evidence of benefit have been acted upon! The study looked at the efficiency...

One airway, one disease - not for everyone!

While 85% of asthmatic patients have rhinitis, only 20-30% with rhinitis have asthma. Together with atopic dermatitis (AD), rhinitis and asthma form a triad that tend to co-exist in patients (multimorbidity). This co-existence raises the possibility of genetic mechanism. Authors...

Don’t be too apologetic: disclosing communication difficulties

People who stutter are frequently considered less intelligent or less confident, and are often discriminated against. These negative perceptions have been found to differ slightly across different cultural groups. For Hebrew speakers in Israel, having a stutter can have a...

A more comprehensive management for eosinophilic chronic rhinosinusitis after FESS

In recent years there has been increasing recognition of eosinophilic chronic rhinosinusitis which, in particular, results in persistent symptoms and recurrence of nasal polyps, even after FESS surgery. It therefore calls for measures adjuvant to FESS to stop persistence of...

Still not smelling

Post-Covid anosmia/hyposmia is a troublesome persistent symptom for lots of patients. Management is still elusive. This was a nationwide survey of ENT practitioners. Of the 715 surveyed members, only 7.4% responded. Most performed a nasal endoscopy, 60% ordered an MRI...

Maxillomandibular advancement and airway morphology

This is a cadaveric study comparing alterations in airway volume. Seven advancements of the maxillomandibular complex were undertaken, each with a 2 mm incremental advancement being scanned with a total of eight scans per cadaver. They showed that comparisons between...

Should we leave a reconstructed auricle exposed?

Microtia results in psychological and functional morbidity and total auricle reconstruction offers the affected individual a more cosmetically pleasing ear. The art of dressing postoperatively can be heterogenous between surgeons. This single-centre retrospective study based in China compared complication rate...

From the editor Sep/Oct 2024

Declan Costello, MA, MBBS, FRCS(ORL-HNS),Consultant Ear, Nose and Throat Surgeon, Wexham Park Hospital, Slough, Berkshire, UK. E: d.costello@nhs.netTW / X: @Voicedoctor_uk This edition marks a milestone for me, as it is exactly 10 years since I started as editor of...

3rd Annual Inner Ear Disorders Therapeutics Summit

The development of next-generation drug-based approaches to treat inner ear disorders is gaining momentum, with multiple INDs approved in the last six months and big pharma making plays to acquire innovative biotechs working on hearing loss. The 3rd Inner Ear...

Biologic therapies for chronic rhinosinusitis with nasal polyps: a new paradigm

Surgery for nasal polyposis has evolved significantly in the last 30 years, and now the medical management may be on the cusp of a revolution. Biologics using monoclonal antibodies to target specific immune pathways have introduced a paradigm shift in...

A place for everything and everything in its place: the practicalities of randomised clinical trials

Will this pill cure tinnitus? Bonnie Millar describes one trial that has investigated the possibility whilst describing the path of drug trials in the UK. Background In the last quarter of 2014, a clinical trial (QUIET-1; ClinicalTrials.gov Identifier: NCT02315508) commenced...