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Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours

Introduction Cancer cases continue to increase worldwide, and­­ head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...

In conversation with Prof Peter Friedland – Reflections on an extraordinary career and life

Our illustrious friend, Harvey Coates, hears about Professor Friedland’s amazing personal journey, ranging from horrifying exposure to violence through to his clinical care for (and friendship with) Nelson Mandela and his prevailing passion for teaching. Professor Peter Friedland. Professor Peter...

Surgical approach to trigeminal neuralgia

This article provides a summary of the operative techniques available for treating patients with trigeminal neuralgia who have medication resistant pain or medication intolerance. Microvascular decompression is performed via suboccipital craniotomy to find and resolve the underlying nerve compression. The...

Vestibular migraine or BPPV?

There are close similarities between benign paroxysmal positional vertigo (BPPV) and vestibular migraine (VM) as both can be presented by positional nystagmus. Though BPPV remains the commonest cause of pure positional vertigo, VM can mimic this condition. This study is...

Can diet alone be used to treat laryngopharyngeal reflux?

In this crossover observational study, a low-fat, low-quick-release sugar, high-protein, alkaline, and plant-based diet was investigated as a single treatment for laryngopharyngeal reflux (LPR). Authors recruited 50 participants with demonstrated LPR on hypopharyngeal-oesophageal multichannel intraluminal impedance-pH-monitoring (HEMII-pH), off acid suppressive...

Human immunodeficiency virus and hearing impairment

With an estimated 36.7 million individuals living with HIV / AIDS and literature reporting that these conditions contribute to hearing loss, it is surprising that more focus and resources are not employed to tackle this major hearing health concern. Yolandé...

Precision and personalised genomic and epigenomic medicine in audiology/hearing loss

A detailed look at the pathogenesis of acquired hearing loss due to exposure to ototoxicity during pregnancy or shortly after birth. Insights from genomic medicine have shown that, along with environmental factors causing epigenetic alterations, hearing loss may be caused...

60th ENT Congress for the South African Society of ORL-OHNS

Dr Greta Niemann, ENT surgeon, Pretoria The 60th Annual ENT Conference held in Pretoria in November was a remarkable event, skilfully organised and offering an exceptional line-up of international and local speakers. This year’s gathering provided a unique opportunity for...

Preoperative prediction of pain outcomes in patients with trigeminal neuralgia

The authors of this retrospective study have developed a preoperative trigeminal neuralgia (TN) grading system for the preoperative prediction of long-term pain relief after microvascular decompression (MVD). Patients who had become refractory to or developed toxicity to carbamazepine or oxycarbamazepine...

Improving cochlear-implant performance in the short- and medium-term

Can bespoke cochlear implant programming strategies reduce the variability seen in patient performance with an implant? Bob Carlyon reviews the current situation and gives us a glimpse of the future. Although many cochlear implant (CI) patients understand speech well in...

Sound Seekers: audiology in the developing world

Kavita Prasad, the current CEO of Soundseekers, is an inspirational woman in a leadership role within the audiology world. Here, she gives us an overview of the scope of the charity and the ways in which they improve the lives...

Hidden hearing loss in humans: cochlear synaptopathy is superseded by cognitive effects when listening to speech in noise

Elizabeth Beach presents an overview of the recent research being undertaken at the National Acoustic Laboratories on speech in noise and its relationship to cochlear synaptopathy. Our team at the National Acoustic Laboratories (NAL) has been investigating hidden hearing loss...