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Is combined two wall decompression approach a better surgical outcome for Grave’s orbitopathy?
This retrospective study looked at the outcome of endoscopic medial wall combined with transcutaneous lateral orbital wall decompression in Graves’ orbitopathy. The following parameters were studied: reduction in proptosis; change in visual acuity and diplopia. A total of 36 orbits...
Anatomic guidelines to endolymphatic sac in transmastoid approach – a cadaveric study
This study involved cadaveric dissection using transmastoid approach in cadaveric embalmed five half heads and posterior fossa approach in fourteen. The sac was identified by electron microscopy. The relatively consistent measurements were the relationship of the operculum to the internal...
A conservative approach to treat ameloblastoma
Ameloblastoma is an odontogenic tumour that is benign but locally aggressive and is associated with local recurrence. They are rare, accounting for 1% of oral tumours, and occur almost exclusively in the jaws. It is more common in the mandible...
IL-25 and nasal polyps, another target
Immune response in chronic rhinosinusitis with nasal polyps (CRSwNP) is mainly via type 2 T-helper (Th2) cells while Th1 cells characterise chronic rhinosinusitis without nasal polyps (CRSsNP) immune response. CRSwNP is heterogeneous on a cytological level causing a varied response...
Follicle stimulating hormone receptors; an aid for the pathologist?
It is well known that Follicle Stimulating Hormone receptors (FSHRs) are found in extra-gonadal tumours such as those within thyroid tissue. This Polish study analysed 44 thyroid resection specimens to look for the presence of these receptors. No mention is...
Interleukins, cilia and polyps
Interleukins (ILs) including IL13 (Th2 cytokine) are inflammatory mediators and their role in asthma has been detailed before. This study explores IL13 receptor expression in chronic rhinosinusitis with nasal polyps (CRSwNP). The authors investigate protein and mRNA expression levels of...
One airway, one disease - not for everyone!
While 85% of asthmatic patients have rhinitis, only 20-30% with rhinitis have asthma. Together with atopic dermatitis (AD), rhinitis and asthma form a triad that tend to co-exist in patients (multimorbidity). This co-existence raises the possibility of genetic mechanism. Authors...Why screen for hearing loss in adults?
Introduction Hearing loss affects over 10 million people in the UK – one in six of the population. Of over 50-year-olds 41.7% are estimated to have some form of hearing loss. This rises to 71.1% of over 70-year-olds, over half...Endolymphatic sac surgery: controversial procedure for the treatment of Ménière’s disease
Landmark Paper: Thomsen J, Bretlau P, Tos M, Johnsen NJ. Ménière’s disease: endolymphatic sac decompression compared with sham (placebo) decompression. Ann N Y Acad Sci 1981;374:820-30. Of all of the chapters in the Landmark Papers book, the chapter that discussed...Current perspectives of tinnitus and its management
Whilst there are various therapeutic options for ameliorating the impact of tinnitus, there is no current approved treatment for attempting to eradicate, or even for reducing, the loudness of tinnitus.European funding for the tinnitus research network TINNET
Over 70 million people in Europe experience tinnitus, and for seven million it creates a debilitating condition. Severe tinnitus is often associated with depression, anxiety and insomnia, resulting in an enormous socio-economic impact [1]. It has been estimated that 13...
