Journal Reviews

Otolaryngology Clinics of North America journal cover image.

How best can we manage Samter’s Triad/AERD?

3 July 2023 | | ENTA - Rhinology / Sinus | Aspirin intolerance, Aspirin-exacerbated respiratory disease, Asthma, Biological agents, Chronic rhinosinusitis with nasal polyposis, NSAID intolerance, Samter's Triad

The classic ‘Samter’s Triad’ of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and aspirin sensitivity is now referred to as aspirin-exacerbated respiratory disease (AERD) or non-steroidal anti-inflammatory-exacerbated respiratory disease. We often come across in our rhinology setting, patients with recalcitrant...

ALLERGY cover

CRSwNP, another monoclonal antibody

1 July 2019 | | ENTA - Rhinology / Sinus | biomarkers, dupilumab, nasal polyposis, nasal secretions, type 2 inflammation

Interleukins 4, 5 and 13 were shown to be important factors in type 2 inflammation, which characterises chronic rhinosinusitis with nasal polyposis (CRSwNP). In CRSwNP non-responders and those who recur short after-surgery monoclonal antibodies might be an answer. Examples include...