The authors of this study investigated the prevalence of acid reflux in the proximal oesophagus and functional gastrointestinal symptoms in patients with posterior laryngitis. They analysed plasma motilin as well as health-related quality of life (HRQOL) questionnaires before and after treatment in 46 patients. Oesophago-gastro-duodenoscopy, 24-h pH monitoring, Plasma motilin analysis and a 36-item short-form questionnaire were completed at inclusion and at follow-up 43±14 months later. Forty percent of patients showed distal acid reflux while 34% showed proximal acid reflux. Only 17% of the 94% patients who received acid reducing treatment showed relief of symptoms. Patients with reflux symptoms had lower plasma motilin levels compared to patients without reflux symptoms. The study concluded that only a minority of patients with posterior laryngitis had LPR and were cured by acid-reducing therapy. However, abnormal plasma motilin levels and functional gastrointestinal symptoms were found in patients with posterior laryngitis and the impaired HRQOL improves over time.