Malignant change of pleomorphic adenoma
Reviewed by Thomas Hampton

Pleomorphic adenoma is the most common salivary gland tumour. The potential to undergo malignant transformation is rare but well described. The authors of this article present a case report of metastasis where the preceding submandibular gland pleomorphic adenoma preserves its benign phenotype. A brief literature search reveals that a review by Knight et al in 2016 found that only 81 cases have ever been reported where histologically, the pleomorphic adenoma retain their benign nature yet demonstrate malignant behaviour.

Metastasizing pleomorphic adenoma case report and review of the literature.
Alshagroud R, Kamoh A, Popat SR, et al.
HEAD AND NECK PATHOLOGY
2017;11(4):487-93.