MRONJ: surgical treatment outcomes and prognostic factors
Reviewed by Stuart Clark

This study from China assessed 197 patients with advanced mandibular disease who underwent radical surgery and had at least 6 months of follow-up. The extent of surgery varied from marginal resection and local flap closure, plate and pedicle flap to fibula free flap. Of these patients, 173 were AAOMS stage III, as one would expect from the delayed diagnosis or failed conservative treatment. They found segmental resection achieved a higher success rate than marginal resection, although no matter what section was undertaken, lesion boundaries were noted to be highly reliant on visual assessment. Fibula free flap demonstrated the highest numerical success rate of 93.8%. They found that reconstruction plates and regional flaps were also successful, although they cautioned about long-term complications such as plate fracture. They also noted that preoperative haemoglobin and serum calcium levels were significant prognostic factors for successful treatment. In addition, hypoalbuminemia and hypoglycaemia were also significant factors that impaired healing of both soft and hard tissue.

Surgical treatment outcomes and prognostic factors in mandibular medication-related osteonecrosis of the jaw.
Chen J, Jia K, Lyu X, An J.
INT J ORAL MAXILLOFAC SURG 
2026;55(8):913–9.