This case series describes the author’s results with repairing lateral sphenoid encephalocoeles in seven patients. Alloderm inlay with abdominal fat onlay and nasoseptal flap onlay repair resulted in a 100% success rate with no recurrence of cerebrospinal fluid (CSF) rhinorrhoea, while Alloderm onlay with contralateral nasoseptal flap and free mucosal graft the results were 0%. No statistically significant benefit of postoperative lumbar drainage was noted in this series. According to the author, Alloderm inlay with autologous fat onlay made the repair more watertight and prevented recurrence of CSF rhinorrhoea. This limited case series, once again highlights the efficacy of the endoscopic approach for CSF rhinorrhoea repair and adds specifically to the literature on lateral sphenoid encephalocoele repairs which are quite rare.