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This interesting review article summarises the status as well as future prospects of organoid technology in our field. Organoids are a mass of cells which are typically cultured in vitro with 3D technology. They simulate miniature tissues and organs and mimic their physiology and pathological structure. The technology for otolaryngology, head neck surgery is still in its infancy but developing rapidly. Hearing loss treatment is likely to be revolutionised by advances in organoid replacement therapies. Organoid models are being created to study nasopharyngeal carcinoma and respiratory viruses. The authors describe the evolution of predictive models for head neck squamous cell carcinoma and thyroid regeneration using organoid technology. Organoids may transform our understanding as well as treatment of otolaryngological and head neck diseases in future. It offers hope as we embark on the New Year!

Application of organoids in otolaryngology: head and neck surgery.
Zhu H, Qu S, Deng Y, et al.
2023; [ePub ahead of print].
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Gauri Mankekar

Department of Otolaryngology-Head Neck Surgery, Louisiana State University Shreveport, Louisiana, USA.

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