Targeted parathyroid adenoma excision via preoperative ultrasound and radionuclide scanning techniques allow accurate localisation of the affected gland, allowing a minimally invasive surgical approach. The authors reviewed 144 cases undergoing surgery for primary hyperparathyroidism. Of these 67 were eligible for day surgery. The non-selection criteria included: patients living alone or too far from the surgical facility, patients over 80 years old, patients with significant comorbidities. Other exclusion criteria included non-visualisation of the adenoma, previous thyroid surgery, anticoagulant uptake or the need for other additional surgeries. Based on such precise criteria only 3% of the selected patients required hospitalisation (bleeding or bradycardia). No postoperative hypocalcaemia was reported in any case. Consequently, day case parathyroidectomy is a feasible and safe technique in carefully selected patients.