Transient diabetes insipidus (DI) after pituitary surgery is not uncommon and its diagnosis fairly obvious. Permanent DI is rare and often depends on the neurosurgeon’s experience. This retrospective study describes a large series of patients with majority undergoing endoscopic transsphenoidal hypophysectomy by a single highly experienced neurosurgeon. The authors report permanent DI in only 4.6% of their patients. DI prevalence rates depended on the pathology. Highest prevalence of DI was observed in craniopharyngiomas and lowest in adenomas. The study describes predictors of transient and permanent DI and outcomes of various sellar pathologies. Although the authors evaluated prevalence of DI, they have not evaluated another potentially dangerous outcome post-hypophysectomy, namely SIADH (syndrome of inadequate antidiuretic hormone).