Serum biomarkers for CRSwNP
Reviewed by Joanna Stephens

This cross-sectional comparative study looked at 50 patients with nasal polyps who, at the time of diagnosis, also had a blood test evaluating serum total IgE, IL-17 and Pentraxin-3. The study assesses whether these blood markers are useful in the diagnosis of nasal polyps, and also whether they correlate with the SNOT-22 and the Lund-Mackay score as markers of severity of disease. The answer is a fairly resounding yes – all three markers correlate with a high SNOT 22 and Lund Mackay score in addition to levels of the three markers and recurrence of polyposis, and all results achieve statistical significance with ease. The authors conclude that there is value in including these blood tests in the preoperative workup, and I would agree it seems these can offer some value in predicting response to treatment and severity of disease.

Evaluation of Serum Total Immunoglbulin E, Interleukin-17 and Pentraxin-3 as Biomarkers for Chronic Rhinosinusitis With Nasal Polyposis.
Hussien H, Habieb M, Hamdan A.
AM J RHINOL ALLERGY
2021;35(5):640-6.