You searched for "Genetic"
Can we predict how much benefit patients will get from ESS with a novel monoclonal antibody
Mepolizumab (Nucala) is a humanised IgG1 monoclonal antibody that acts as an IL-5 antagonist. It has been shown to be highly effective in treating severe asthma. It is hypothesised that it will be effective for patients with recalcitrant CRSwNP. This...
How interaural level differences differ between children with bilateral cochlear implants and their normally-hearing peers
A group in the Netherlands investigated interaural level differences (ILDs) in children who were bilaterally implanted with cochlear implants (CIs) and compared their performance to their normally-hearing peers. ILDs are used to localise sound and rely on the high-frequency cues....
Hearing rehabilitation for patients with chronic otitis media
Chronic otitis media (COM) commonly causes associated hearing loss. The authors performed a review of the literature, discussed challenges of restoring hearing in patients with COM and potential future work in reporting results both in terms of hearing outcomes and...
Do adhesions actually cause nasal blockage?
All of us who perform nasal surgery are familiar with the disappointing presence of nasal adhesions (NA) or synechiae in our postop patients. These can often lead to patients deriving less perceived benefit from their surgery than that which they...
Transcutaneous vs. percutaneous bone conduction devices
Bone conduction devices (BCD) have proven to be effective options for hearing amplification in patients who are not candidates for conventional hearing aids. This study prospectively surveyed 70 patients with BCD using the COSI (Client Oriented Scale of Improvement) and...
Does pregabalin help with post-tonsillectomy pain?
This is a small double-blind randomised controlled trial conducted on tonsillectomy and lateral pharyngoplasty operations. Both of these operations are terrifically painful, and I am sure most of us are looking for a way of reducing the suffering for our...
Long-term results for dupilumab are very promising!
Eosinophilic chronic rhinosinusitis (eCRS) is complicated by frequent early and aggressive recurrence of polyps after both medical and surgical treatment regimes. Dupilumab is an anti-IL-4/IL-3 receptor monoclonal antibody and has been previously studied in the SINUS-52 study, with an observation...
A viable solution for isolated post-nasal drip?
This retrospective, single-centre case series looked at a cohort of patients with postnasal drip as their primary symptom. Exclusions were patients with chronic rhinosinusitis. The interventions offered were temperature-controlled radio frequency (TCRF) ablation of the posterior nasal nerve delivered by...
The future of fall detection
Falls are a major global health burden. According to the World Health Organization, they are the second leading cause of unintentional injury deaths worldwide, with adults older than 65 at the greatest risk of a fatal fall. For every death...
