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The polyp shrinker
Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...
Biologicals for severe chronic rhinosinusitis with nasal polyps. Any use?
Recent advances and knowledge of inflammatory endotypes of chronic rhinosinusitis with nasal polyps (CRSwNP) led to introduction of biological agents such as monoclonal antibodies targeting IgE (omalizumab) and Interleukins (ILs) such as IL4R alpha (dupilumab) and IL5. The European Academy...An audio inclusivity project
Hackney has become the hub of a new initiative for audio inclusivity, with three of the London borough's leading music venues now boasting state-of-the-art, audio-inclusive acoustics. Audio inclusivity is a concept developed to ensure venues and experiences are accessible and welcoming for people of all hearing abilities, including those who are noise-sensitive.Thyroid nodules – time for a rational imaging approach
“The more you know, the harder it is to take decisive action. Once you become informed, you start seeing complexities and shades of gray. You realize that nothing is as clear as it first appears. Ultimately, knowledge is paralyzing.” Calvin,...Prednisolone and/or acyclovir for Bell’s palsy
Landmark Paper: Sullivan FM, Swan IRC, Donnan PT, et al. Early treatment with prednisolone or acyclovir in Bell’s Palsy. N Engl J Med 2007;357(16):1598-607. Facial nerve paralysis as a consequence of Bell’s palsy can result in devastating long-term effects on...OBITUARY: Dr David Pothier
David Pothier passed away on July 27, 2018 in the early hours of the morning following a struggle with recurrent brain cancer. His passing extinguished a brilliant light, the likes of which few of us will witness in our lifetime....KTP laser in the office
KTP laser surgery offers a new way of selectively targeting microvasculature within laryngeal lesions and leaving normal surrounding tissues like epithelium and lamina propria intact – and thus preserving physiological phonation. This kind of selective photoangiolysis can be performed in...In-office management of subglottic and tracheal stenosis: balloon dilation, laser treatment and steroid injection
Laryngology continues to advance since its development as a subspecialty at the turn of the century. Rarely performed operations restricted to the surgical theatre can now be undertaken in the outpatient / office environment. This detailed article demonstrates, in a...In conversation with Professor Patrick Gullane: My life in Otolaryngology-Head & Neck Surgery
Fellowship RCSEng 2009. Patrick, as you have recently ‘stepped down’ as Chairman and Chief of ORL-HNS at Toronto General Hospital, what next? Firstly, so often I have been asked why I selected this career path, from a quote by Johnny...
