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Cancer genetics and signalling pathways in ENT – a review and discussion of how this can be applied to rare tumours

Introduction Cancer cases continue to increase worldwide, and­­ head and neck cancer is a major global health issue, with an estimated global burden of over 630,000 new cases and over 350,000 deaths per year [1]. The term ‘head and neck...

Pre-clinical development of magnetic delivery of therapy to middle and inner ears

Why are we developing this technology? A key problem in drug delivery is getting the therapy to the right place in the body, which is especially challenging for targets that are small, deep and are protected or surrounded by anatomical...

Temporal bone trauma

Introduction Temporal bone injuries represent one of the more complex management problems presenting to the otolaryngologist. This is largely due to difficulties in assessment and the frequent delays in referral, often as a result of other injuries demanding more immediate...

ENT and evidence-based medicine: How do they benefit each other?

How do we assess evidence, and how should ENT surgeons use EBM? Evidence-based medicine (EBM) is the practice of medicine based upon high quality scientific research. There are several formal definitions of EBM, the most widely quoted being that of...

Systemic agents in thyroid cancer

For those patients who have disseminated or unresectable thyroid cancer, Dr Arabella Hunt and Dr Kate Newbold review systemic treatments, their differences, toxicities and outcomes. Thyroid cancer is the most common endocrine malignancy. It is subdivided into differentiated (papillary, follicular...

Greener pastures? Reflections from UK ENT surgeons now practising abroad

Ever considered practising ENT abroad? Here are some experiences of previously UK-based ENT surgeons who took the plunge and are now plying their trade in distant lands. Andrew McCombe ENT ConsultantDate of migration: December 2015Place of work: Mediclinic City Hospital,...

In conversation with George Browning, author of Browning’s Audiology for Clinicians

Professor George Browning. It is one of those superbly bright August mornings in London’s West End. It gives Lamb’s Conduit Street, where I’m meeting George Browning, an almost timeless feeling. The café we meet at is bustling and noisy, and...

Commentary: dementia, hearing loss, and the danger of professional rabbit holes

The Lancet, a world-leading general medical journal, has a global impact. Its commissioned report into dementia prevention, intervention and care has been cited over 6000 times and has further been reviewed and updated in 2020 and now 2024. Here, Profs...