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Stem cells in nasal polyposis

Chronic rhinosinusitis with nasal polyps (CRSwNP) is common and is multifactorial with increased T-helper 2 response and active role of interleukin 5. It can be associated with asthma and control of CRSwNP improves lower airway disease. Due to constant cellular...

The polyp shrinker

Inflammatory markers, including T2 cells beta common (βc) cytokines IL-3, IL5 and granulocyte-macrophage colony-stimulating factor (GM-CSF), are known to play an important role in chronic rhinosinusitis with nasal polyps (CRSwNP). CSL311, a monoclonal antibody (mAb), was developed to target human...

A diagnosis-based scoring system to predict outcomes in necrotising otitis externa

Patients admitted with necrotising otitis externa have increased six-fold in the last 10 years. The prognosis is variable and dependent on co-existing morbidities. Charlston Comorbidity Index (CCI) is a weighted comorbidity scoring method, based on the presence or absence of...

Foretelling: post-stroke recovery of dysphagia is predicted by cognition

Around two thirds of people in the acute phase of stroke recovery will experience dysphagia. Up to six months following a stroke this may be present in 13-18% of cases. The degree of cognitive impairment seems to be associated with...

Can PRP injections treat atrophic rhinitis?

As we all know, atrophic rhinitis is a thankfully rare but debilitating condition characterised by nasal obstruction, dryness, crusting and foul smell (ozaena). There are currently minimal treatment options available, none of which have proven particularly effective. The authors present...