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The changing landscape for hearing loss therapeutics: novel advances of gene and cell therapies
Recent years have seen advances in hearing loss therapeutics, with novel treatments trialled in humans, and others nearing promising first-in-kind clinical trials. First successful clinical trials for a specific form of genetic hearing loss Very exciting news has emerged in...The common frontal sinusotomy (Lothrop) and chronic rhinosinusitis
As our understanding of the pathophysiology of CRS evolves, so do our treatment strategies. It is accepted that in many cases, the main role of surgery is to allow better penetration of topical therapies to the sinus cavities. What, then,...
A mouth-rinse test that can screen for oral cancer?
This paper presents a promising screening tool for oral cancer – using a simple chlorhexidine mouth-rinse. The hypermethylated ZNF582 and PAX1 markers were chosen based on previous studies using oral scraping methods of collection and have been shown to be...In conversation with Dr John Woo and Mr Derek Skinner
Dr John Woo and Mr Derek Skinner have between them an absolute wealth of experience and expertise in the fields of surgical training and specialist examinations. Here, they tell us about their involvement in surgical education, and explain some of...
The impact of rhino-sinusitis treatment on olfaction
This study included 28 adults prospectively enrolled between March 2011 and May 2013 into a non-randomised, multi-institutional cohort. Adults electing endoscopic sinus surgery experienced gains in olfaction comparable to adults electing continued medical management. The evidence in this study comparing...Rhinology Issue I
To skip directly to features, click the links below: Welcome from the editor - by Prof Claire Hopkins Real-life experience in using biologic therapies in the management of CRS with nasal polyps - by Eugenio de Corso Sinus surgery in...The future of inner ear drug delivery
The techniques for delivering drugs to the inner ear system are evolving. Jeffrey Harris considers the myths, the facts and the potential for drug delivery innovations and how they can improve tomorrow’s hearing outcomes. The inner ear’s delicate membranous structure,...
Epley manoeuvre angles
Posterior canal benign paroxysmal positional vertigo (PC-BPPV) is a common vestibular cause of dizziness regularly encountered in the outpatient clinic. The condition is often diagnosed with a positive Dix-Hallpike manoeuvre (DHM) – turning the patient’s head 45 degrees to the...What you need to know about recent advances in genetics of hearing loss in the newborn
Identifying the underlying genetic cause of hearing loss in newborns can improve dramatically the early diagnosis and appropriate intervention. Hearing loss is the most common sensory disorder at birth, affecting approximately two out of 1000 newborns [1]. Congenital impaired hearing...In conversation with Professor Claire Hopkins
There can be few ENT surgeons who have had such a pivotal role in the COVID pandemic as Claire Hopkins. She has been instrumental in changing the diagnostic criteria, and has been a frequent presence in the media, as Sean...Lies, damned lies and relative risk reduction
Chris Potter has a thing or two to say about the use of statistics and, in doing so, he takes us to a Friday night steak house that is prone to airway disasters and on a short tour of his...
