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1907 results found

The structure and function of DNA

DNA structure and replication Genetic information within multicellular organisms, including man, is stored in molecules of deoxyribonucleic acid (DNA), which reside within the chromosomes of each cell nucleus. A DNA molecule consists of two very long chains, or strands, of...

Staphylococcus aureus as a cause of refractory chronic rhinosinusitis

Staphylococcus aureus has long been linked to chronic rhinosinusitis, particularly recalcitrant cases. In this article, Alkis Psaltis describes how newer techniques have shown higher rates of S. aureus infection than were previously thought, and explains how the bacteria are able...

Timing of surgery in chronic rhinosinusitis: does it matter?

While many patients with chronic rhinosinusitis respond to medical treatment, some do not. The next step for these patients is surgery, but how soon should this be offered? Sooner rather than later seems to be the answer, as Claire Hopkins...

Developing medical devices for children: opportunities and challenges

The development of medical devices for infants and children lags significantly behind the development of devices for adults. While in the United States the Food and Drug Administration (FDA) has set up incentives for developing child age-specific pharmaceuticals, there is...

Discovery in the genetics of complex disease: Otitis media

Otitis media (OM), a common disease of childhood, is considered to be a complex trait with multiple genetic and environmental factors expected to contribute to a child’s risk of developing recurrent acute OM (rAOM; ≥3 episodes in 6 months or...

William Hunter’s work on the anatomy of the human ear

The Hunterian Society offers an annual award for an essay and presentation on a subject of relevance to John or William Hunter, or medicine in the 18th Century. This article is based on Emma Stapleton’s 2014 winning essay, which was...

Advances in vestibular function testing

Vestibular function testing has historically been limited by difficulties in testing individual parts of the vestibular apparatus. Jas Sandhu describes new tests available to clinicians that address this problem. Advances in vestibular function testing Vestibular function testing has historically been...

General overview of endoscopic ear surgery: advantages and principles

The philosophy of endoscopic ear surgery presents surgeons with a tricky concept – does the magnificent view make up for the fact I need to operate with one hand? In this article, Jane Lea discusses the advantages of operating transcanal...

Cochlear implant referral: how can we do better?

Considerable progress has been made over the last few years in improving access to cochlear implantation (CI) in the UK for children and adults with severe to profound deafness. But we are still not treating children early enough, and we...

Semi implantable bone conduction devices: challenges and developments

Bone conduction mechanisms and history of bone conduction aids Bone conduction hearing devices work by stimulating hair cells via the bone conduction hearing pathways. These pathways are less well understood than the air conduction pathways, but recent research has shown...

Type 1 thyroplasty using a novel and inflatable implant from APrevent® VOIS

Unilateral vocal cord immobility severely impacts voice, swallowing, and airway functions. A novel approach offers adjustable medialisation for improved patient outcomes. Unilateral vocal cord immobility (UVCI) can cause significant disability to voice, swallowing, and airway functions. Patients with UVCI may...

The ‘umbrella furling’ deflation technique for cuffed tracheostomy tube - a useful tip for an easier tracheostomy insertion

In this article, the authors describe a quick and effective technique to assist with the maximal deflation of a tracheostomy tube cuff prior to insertion, thus making the process easier with less chance of damage to the cuff and a...