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Investigation of the role of KPNA2 biomarker in oral SCC invasiveness
This edition of Head and Neck has a strong focus on studies using immunohistochemistry (IHC) to elucidate potential roles of various cell-signalling molecules in both HNSCC and thyroid cancer. The ‘cellular-protein heavy’ title of this article may be off-putting to...
Peripheral nerve stimulation for chronic refractory pain
Peripheral nerve stimulation (PNS) plays an important role in treating chronic refractory pain syndromes that manifest in limited distributions and overlap with areas of neurologic innervation. The process is generally thought to capitalise on the inhibition and activation of pain-related...New trustees for Tinnitus UK
The Tinnitus UK team at a recent roadshow event. Tinnitus UK has appointed a new Chair of the Board of Trustees, Pierre Espinasse, as well as a number of new board members. Pierre is a former chief executive of a...In conversation with Miss Sujata De: Chair of the ESPO 2023 Local Programme Committee
Su De is one of the UK’s most prominent paediatric ORL surgeons, and has a leading role in planning ESPO 2023. Hannah Emerson caught up with Su recently to explore some of her thoughts and her plans for ESPO. You’ve...Vicarious (nasal) menstruation
Hippocrates himself is known to have said that when a woman’s menses are due, but instead of the usual vaginal menstrual flow, she has a haemorrhage from the nose, then this is a sure sign of pregnancy [1]. Artist’s impression...RSM Laryngology & Rhinology: the year ahead
As the president of the RSM’s Laryngology & Rhinology Section for the 2022-23 academic year, my aim is to centre the education programme around our trainees, with a real emphasis on inspiring the future generation of ENT surgeons.In conversation with Diana Terry: Winner of the ‘What Does Sound Look Like to You?’ art competition
The ‘What Does Sound Look Like to You?’ art competition, supported by ENT & Audiology News and Manchester Art Gallery, attracted many impressive entries! They were judged by HUGS Chair, Richard Bircher, along with Fiona Corridan, curator of Grayson’s Art...
Therapeutic ultrasound for tumours
This review article provides details about the potential applications of transcranial focused ultrasound (FUS), its mechanism of action and the studies that have set the basis for its use in neuro-oncology. FUS is an emerging modality of therapy for various...
Laryngeal oedema as a side-effect of tyrosine kinase inhibitor therapy
Tyrosine kinase inhibitors (TKIs) such as Imatinib are increasingly being used to treat haematological and solid malignancies. These agents have revolutionised the treatment of chronic myeloid leukaemia in particular. Although better tolerated than most conventional chemotherapy drugs, multiple side-effects have...
A drug to prevent hearing loss caused by ototoxic therapeutics
This editorial briefly highlights the progress made in discovering a compound named ORC-13661, which shows the potential to alter the response of hair cells to ototoxic medication. In the late 1980s, inner hair cells that were lost secondary to noise...
Tinnitus in patients on therapy with PPI and in PPI non–users
Tinnitus is a chronic and debilitating condition and approximately 10% of the population is afflicted. A myriad of pharmacological treatments for tinnitus are available but only a few controlled studies have shown positive results. The relationship between proton pump inhibitors...
