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A new era in the treatment of recalcitrant nasal polyps?
Chronic rhinosinusitis with nasal polyps (CRSwNP) can be difficult to treat effectively in patients with aggressive or recalcitrant disease. Omalizumab (Xolair) is a monoclonal anti-IgE antibody with proven benefits for patients with moderate/severe asthma and CRSwNP, but this study looks...
Eosinophilic or not eosinophilic: dupilumab seems to work
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammation with interleukin (IL)-4, IL-13, and IL-5. Tissue eosinophilia in nasal polyps dramatically increased over a 10-20-year period. Classification of the severity of eosinophil status is expected to lead to...
Epithelial risk factors
This review paper from Barcelona retrospectively assesses patients diagnosed with oral epithelial dysplasia between 1995-2014 and followed up until 2017. In total, 144 cases were noted, of which 42% progressed to an oral cancer by the time of review in...
Factors influencing transformation of laryngeal dysplasia to malignancy in a 10-year review
Laryngeal dysplasia has a propensity to change into malignancy, the generally reported rate of this being about 14%. In this retrospective study of 125 patients, the authors have assessed the severity of dysplasia in relation to the incidence and time...
Benign positional paroxysmal vertigo manoeuvres in children and adolescents: a systematic review
In this paper of Saniasiaya et al, the literature review is conducted in accordance to the PRISMA consensus, aiming to investigate the outcomes of canalith repositioning manoeuvres (CRM) to treat benign paroxysmal positional vertigo (BPPV) in a paediatric and young...
Non-surgical and surgical management of arytenoids granuloma
Arytenoid granulomas are often a sequelae of laryngopharyngeal reflux (LPR). Unless there is suspicion of malignancy, they require a very balanced approach between conservative management and surgical intervention. The authors present a series of 62 patients with whom the primary...
Evolution of salivary gland pathology classifications
Targeted therapies for malignant salivary gland tumours have changed the treatment paradigm and therapy approaches. Better outcomes are now feasible. Choosing the treatment method requires a clear classification of the lesions. The authors of this paper reviewed the World Health...
Organoids in otolaryngology
This interesting review article summarises the status as well as future prospects of organoid technology in our field. Organoids are a mass of cells which are typically cultured in vitro with 3D technology. They simulate miniature tissues and organs and...
Surgical variations in maxillomandibular surgery treating sleep apnoea
This is a scoping review further highlighting the success in curing sleep apnoea with a maxillomandibular complex advancement. The variations outlined are on East and Southeast Asian patients to reduce the aesthetic concern of bi-maxillary protrusion when large advancements are...
Neonatal nasal stenosis - conservative approach
The authors retrospectively evaluated the efficacy of heated humidified high-flow nasal cannula (HFNC) in neonates with nasal stenosis for this study. Of the six infants included in the study, five had congenital pyriform aperture stenosis. Three of these five also...
Cochlear implantation in inner ear schwannoma patients
Inner ear schwannomas (IES) are rare. Patients with IES tend to lose their hearing. Surgery is a treatment option, but it leads to complete loss of hearing. Other treatment options include stereotactic radiosurgery (SRS) and watchful waiting (WW). The authors...
