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Chronic rhinosinusitis with nasal polyps (CRSwNP) can be difficult to treat effectively in patients with aggressive or recalcitrant disease. Omalizumab (Xolair) is a monoclonal anti-IgE antibody with proven benefits for patients with moderate/severe asthma and CRSwNP, but this study looks at patients with mild asthma and CRSwNP. They used a retrospective review of notes for 23 patients treated with Omalizumab for a period between 11 and 47 months. They observed a significant improvement in reduction of nasal polyp size and in SNOT-22 scores, and the findings suggest that Omalizumab is a good treatment option for patients with mild asthma and CRSwNP.

Effects of Omalizumab treatment in patients with recalcitrant nasal poly posits and mild asthma: A multi center retrospective study.
Armengot-Carceller M, Gómez-Gómez MJ, García-Navalón C, et al.
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Joanna Stephens

United Lincolnshire Hospitals NHS Trust, UK.

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